MR-intracranial pressure (ICP): A method to measure intracranial elastance and pressure noninvasively by means of MR imaging: Baboon and human study
MR-intracranial pressure (ICP): A method to measure intracranial elastance and pressure noninvasively by means of MR imaging: Baboon and human study
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DOI：
10.1148/radiology.217.3.r00dc42877
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发表时间：
2000-12-01
期刊：
影响因子：
19.7
通讯作者：
Lichtor, T
中科院分区：
文献类型：
--
作者：
Alperin, NJ;Lee, SH;Lichtor, T
目的：建立一种无创测量颅内弹性和颅内压的方法。材料和方法：根据脑脊液(CSF)和血流的磁共振成像(MR)测量，计算颅内体积和压力的变化。根据经颅脑脊液净流量和血容量流率计算血容量变化。根据脑脊液速度计算出的脑脊液压力梯度的变化导致了压力的变化。根据压力与体积变化之比，推导出弹性指数。对5名健康志愿者进行4~5次弹性指数测量，建立弹性指数测量的重复性。在磁共振成像中，对5名使用脑室导管的患者的弹性指数进行了测量，并与有创的颅内压测量进行了比较。通过对8名健康志愿者和4名慢性ICP升高患者的25项测量，建立了假阳性和假阴性率。结果：人体弹性指数的分数SD平均值为19.6%。5例使用脑室导管的患者的弹性指数与有创性测量的颅内压有良好的相关性(R-2=0.965；P<；0.005)。8名健康志愿者磁共振成像的ICP为4.2-12.4 mm Hg，均在正常范围内。4例慢性颅内压升高患者中有3例的测量结果为20.5-34.0 mm Hg，显著高于正常范围。结论：在较大范围的ICP值范围内，磁共振成像得出的弹性指数与ICP值相关。这项技术的敏感性可以区分正常和升高的颅内压。
PURPOSE: To develop a noninvasive method for intracranial elastance and intracranial pressure (ICP) measurement.MATERIALS AND METHODS: Intracranial volume and pressure changes were calculated from magnetic resonance (MR) imaging measurements of cerebrospinal fluid (CSF) and blood flow. The volume change was calculated from the net transcranial CSF and blood volumetric flow rates. The change in pressure was derived from the change in the CSF pressure gradient calculated from CSF velocity. An elastance index was derived from the ratio of pressure to volume change. The reproducibility of the elastance index measurement was established from four to five measurements in five healthy volunteers. The elastance index was measured and compared with invasive ICP measurements in five patients with an intraventricular catheter at MR imaging. False-positive and false-negative rates were established by using 25 measurements in eight healthy volunteers and six in four patients with chronically elevated ICP.RESULTS: The mean of the fractional SD of the elastance index in humans was 19.6%. The elastance index in the five patients with intraventricular catheters correlated well with the invasively measured ICP (R-2 = 0.965; P < .005). MR imaging-derived ICPs in the eight healthy volunteers were 4.2-12.4 mm Hg, all within normal range. Measurements in three of the four patients with chronically elevated ICP were 20.5-34.0 mm Hg, substantially higher than the normal limit.CONCLUSION: MR imaging-derived elastance index correlates with ICP over a wide range of ICP values. The sensitivity of the technique allows differentiation between normal and elevated ICP.