NADPH oxidases and oxidase crosstalk in cardiovascular diseases: novel therapeutic targets.
NADPH oxidases and oxidase crosstalk in cardiovascular diseases: novel therapeutic targets.
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DOI：
10.1038/s41569-019-0260-8
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发表时间：
2020-03
期刊：
影响因子：
--
通讯作者：
Cai H
中科院分区：
文献类型：
--
作者：
Zhang Y;Murugesan P;Huang K;Cai H
活性氧（ROS）依赖性的产生是持续氧化应激的基础，它涉及心血管疾病的发病机制，如高血压、主动脉瘤、高胆固醇血症、动脉粥样硬化、糖尿病血管并发症、心脏缺血-再灌注损伤、心肌梗死、心力衰竭和心律失常。不同氧化酶或氧化酶系统之间的相互作用在诱导持续氧化应激中的作用已被深入研究。在这篇综述中，我们讨论了每种氧化酶组分的病理生物学的最新数据，不同氧化酶组分之间的复杂串扰以及这种串扰在介导心血管疾病过程中的后果，重点关注在特定心血管疾病中激活的特定NADPH氧化酶（NOX）异构体的核心作用。对这些机制的进一步了解可能有助于开发针对这些氧化酶系统及其相互作用的新型治疗剂，从而有效地预防和治疗心血管疾病。
Reactive oxygen species (ROS)-dependent production of ROS underlies sustained oxidative stress, which has been implicated in the pathogenesis of cardiovascular diseases such as hypertension, aortic aneurysm, hypercholesterolaemia, atherosclerosis, diabetic vascular complications, cardiac ischaemia–reperfusion injury, myocardial infarction, heart failure and cardiac arrhythmias. Interactions between different oxidases or oxidase systems have been intensively investigated for their roles in inducing sustained oxidative stress. In this Review, we discuss the latest data on the pathobiology of each oxidase component, the complex crosstalk between different oxidase components and the consequences of this crosstalk in mediating cardiovascular disease processes, focusing on the central role of particular NADPH oxidase (NOX) isoforms that are activated in specific cardiovascular diseases. An improved understanding of these mechanisms might facilitate the development of novel therapeutic agents targeting these oxidase systems and their interactions, which could be effective in the prevention and treatment of cardiovascular disorders.
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