Ovarian teratoma-associated anti-NMDAR encephalitis: a systematic review of reported cases.
Ovarian teratoma-associated anti-NMDAR encephalitis: a systematic review of reported cases.
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DOI：
10.1186/s13023-014-0157-x
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发表时间：
2014-10-14
影响因子：
3.7
通讯作者：
Martín-Estefanía C
中科院分区：
文献类型：
--
作者：
Acién P;Acién M;Ruiz-Maciá E;Martín-Estefanía C
卵巢畸胎瘤与抗N-甲基-D-天冬氨酸受体（NMDAR）脑炎的相关性是一种严重且可能致命的病理学，发生于年轻女性，但认识不足。我们的目标是分析这种关联的患病率和结果，并提高对这种病理学的认识。考虑MEDLINE和SCOPUS中2013年11月30日之前发表的所有研究，包括检索词：“脑炎”和“畸胎瘤”。纳入了报告1例或多例抗NMDAR脑炎和确诊卵巢畸胎瘤（174例）的所有文章（119例）。未应用语言限制。没有卵巢畸胎瘤证据的可疑病例（n = 40）和另一种类型的脑炎也与卵巢畸胎瘤（n = 20）进行了比较和讨论。收集文献和病例报告、手术和结局资料。不同国家和大陆的已发表病例分布不均匀，这可能与发展水平和卫生保健有关。患者的平均年龄为24岁，大多数病例（74%）可通过显微镜或尸检发现成熟畸胎瘤。临床表现以精神症状和行为改变为特征，手术延迟的中位数为28天。12名妇女死亡（7%），最常见的是脑炎相关并发症。总之，卵巢畸胎瘤和抗NMDAR脑炎的关联在许多国家和妇科医生中相对未知或未报告。除了通过抗NMDAR抗体的存在进行诊断确认外，还必须强调对行为变化的高度认识、通过经阴道超声进行诊断和随后的肿瘤切除。本文的在线版本（doi：10.1186/s13023-014-0157-x）包含补充材料，可供授权用户使用。
The association of ovarian teratoma and anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is a serious and potentially fatal pathology that occurs in young women and that is under-recognized. Our objectives were to analyze prevalence and outcome of this association, and increase awareness over this pathology. MEDLINE and SCOPUS for all studies published prior to November 30, 2013 including the search terms: “encephalitis” and “teratoma” were considered. All articles (119) reporting one or more cases of anti-NMDAR encephalitis and confirmed ovarian teratoma (174 cases) were included. No language restrictions were applied. Suspicious cases with no evidence of ovarian teratoma (n = 40) and another type of encephalitis also associated to ovarian teratoma (n = 20) were also considered for comparison and discussion. Data of publication and case report, surgery and outcome were collected. The distribution of published cases is heterogeneous among different countries and continents, probably in relation with level of development and health care. The mean patient age is 24 years and in the majority of cases (74%), a mature teratoma was identified, sometimes microscopically following ovarian removal or at autopsy. The clinical presentation featured psychiatric symptoms and behavioural changes, with a median delay for surgery of 28 days. Twelve women died (7%), most frequently from encephalitis-related complications. In conclusion, the association ovarian teratoma and anti-NMDAR encephalitis is relatively unknown or not reported in many countries and among gynecologists. Heightened recognition of behavioral changes, diagnosis through transvaginal ultrasound and subsequent tumor removal in addition to diagnostic confirmation through the presence of anti-NMDAR antibodies must be emphasized. The online version of this article (doi:10.1186/s13023-014-0157-x) contains supplementary material, which is available to authorized users.
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影响因子：
20.4
作者：
Kawahara, Katsunobu;Miyawaki, Michiyo;Kumamoto, Toshihide
通讯作者：
Kumamoto, Toshihide
影响因子：
1.2
作者：
Kleyensteuber, Brian;Ruterbusch, Victor;Loeffler, George
通讯作者：
Loeffler, George
影响因子：
9.8
作者：
Naoura, Iptissem;Didelot, Adrien;Koskas, Martin
通讯作者：
Koskas, Martin
DOI：
10.1016/j.jpeds.2012.10.011
发表时间：
2013-04
期刊：
The Journal of pediatrics
影响因子：
--
作者：
Armangue T;Titulaer MJ;Málaga I;Bataller L;Gabilondo I;Graus F;Dalmau J;Spanish Anti-N-methyl-D-Aspartate Receptor (NMDAR) Encephalitis Work Group
通讯作者：
Spanish Anti-N-methyl-D-Aspartate Receptor (NMDAR) Encephalitis Work Group
卵巢切除术尽管在抗NMDA受体脑炎中进行了阴性成像：甚至迟到。
影响因子：
0.9
作者：
Boeck AL;Logemann F;Krauß T;Hussein K;Bültmann E;Trebst C;Stangel M
通讯作者：
Stangel M