Embryonic expression of the mRNA for the rat homologue of the fusin/CXCR-4 HIV-1 co-receptor
Embryonic expression of the mRNA for the rat homologue of the fusin/CXCR-4 HIV-1 co-receptor
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DOI：
10.1016/s0165-5728(97)00117-3
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发表时间：
1997-11-01
影响因子：
3.3
通讯作者：
Larhammar, D
中科院分区：
文献类型：
--
作者：
Jazin, EE;Soderstrom, B;Larhammar, D
我们之前已经克隆了一种人类受体，最近被证明是T=嗜嗜性HIV-1毒株进入CD4+细胞的辅助因子，现在被命名为Fusin。基质衍生因子-1(SDF-1)是Fusin的内源性配体，也称为CXCR-4。在这里，我们显示了Fusin/CXCR-4mRNA在大鼠个体发育过程中的分布。胚胎第9天左右开始表达，在发育过程中，胸腺和脑的增殖区表达较高。我们的结果支持：(1)Fusin/CXCR-4可能在脑发育和免疫系统中具有双重作用；(2)SDF-1在脑发育中具有作用或该受体存在额外的生理配体；(3)CD4和Fusin/CXCR-4的共同表达可能使胎儿在发育过程中对HIV感染易感。(C)1997年爱思唯尔科学公司。
We have previously cloned a human receptor recently shown to be a cofactor for entry of T = tropic HIV-1 strains into CD4 + cells, now named fusin. Stromal derived factor-1 (SDF-1) is an endogenous ligand for fusin, also called CXCR-4. Here we show the distribution of fusin/CXCR-4 mRNA during ontogeny in the rat. The onset of mRNA expression is around embryonic day 9 and the mRNA expression is high in the thymus as well as proliferative areas of the brain during development. Our results su est: (1) that fusin/CXCR-4 might have a dual role in both brain development and the immune system; (2) that SDF-1 has a role in brain development or that additional physiological ligands exist for this receptor; (3) co-expression of CD4 and fusin/CXCR-4 may make fetuses susceptible to HIV infection during development. (C) 1997 Elsevier Science B.V.