BIOSTATISTICAL ANALYSIS OF THE MICRONUCLEUS MUTAGENICITY ASSAY BASED ON THE ASSUMPTION OF A MIXING DISTRIBUTION
BIOSTATISTICAL ANALYSIS OF THE MICRONUCLEUS MUTAGENICITY ASSAY BASED ON THE ASSUMPTION OF A MIXING DISTRIBUTION
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DOI：
10.1289/ehp.94102s1121
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发表时间：
1994-01-01
影响因子：
10.4
通讯作者：
HOTHORN, L
中科院分区：
文献类型：
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作者：
HOTHORN, L
体内微核试验可通过比较几个剂量组与对照组的微核（MN）数量进行分析。在一些出版物中，即使在未经治疗的历史对照组中，也难以估计MN的适当分布。Mitchell等人描述了存在更易感应答者亚群。基于这种亚群的假设，将评分检验用于剂量组内应答者和非应答者的混合分布（行为与未给药对照动物相同）。这些测试的功率行为的特点与模拟研究。即使在每组只有5只动物的实际和重要的指导情况下，也可以显示评分测试的优势。
The in vivo micronucleus assay can be analyzed by comparing the number of micronuclei (MN) of several dose groups with those of a control group. In several publications, difficulties arose in estimating a suitable distribution for MN, even in the untreated historical control groups. Mitchell et al. described the presence of a subpopulation of more susceptible responders. Based on this assumption of such a subpopulation, score tests were used for the mixing distribution of responders and nonresponders (behavior same as in untreated control animals) within the dose groups. The power behavior of these tests was characterized with a simulation study. The advantage of score tests can be shown, even in the practical and important guideline case of only five animals per group.