Polymeric nanoparticle preparation that eradicates tumors
Polymeric nanoparticle preparation that eradicates tumors
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DOI：
10.1021/nl0519229
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发表时间：
2005-12-01
期刊：
影响因子：
10.8
通讯作者：
Weissleder, R
中科院分区：
文献类型：
--
作者：
McCarthy, JR;Perez, JM;Weissleder, R
我们报道了封装光敏剂内消旋四苯基卟啉醇的聚（乳酸-乙醇酸）纳米颗粒的生产。这些纳米颗粒在全身给药后是稳定且无光毒性的。细胞内化后，光敏剂从纳米颗粒中释放出来，并变得具有高度光毒性。可见光照射可特异性杀死多种癌细胞系。重要的是，体内实验表明小鼠模型中的癌症被完全根除。具有选择性光毒性的光敏剂的概念应该在癌症治疗中具有广泛的应用。
We report the production of poly(lactic-co-glycolic acid) nanoparticles that encapsulate the photosensitizer meso-tetraphenylporpholactol. These nanoparticles are stable and nonphototoxic upon systemic administration. Upon cellular internalization, the photosensitizer is released from the nanoparticle and becomes highly phototoxic. Irradiation with visible light results in cell-specific killing of several cancer cell lines. Importantly, in vivo experiments show complete eradication of cancers in mouse models. The concept of photosensitizers with selective phototoxicity should have widespread applications in cancer therapy.