Low follicular fluid IL-6 levels in IVF patients are associated with increased likelihood of clinical pregnancy
Low follicular fluid IL-6 levels in IVF patients are associated with increased likelihood of clinical pregnancy
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DOI：
10.1007/s10815-010-9502-8
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发表时间：
2011-03-01
影响因子：
3.1
通讯作者：
Pal, Lubna
中科院分区：
文献类型：
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作者：
Altun, Tugba;Jindal, Sangita;Pal, Lubna
目的探讨IVF-ET周期中卵泡液IL-6水平与卵巢反应及临床妊娠的关系。方法收集每例患者14mm卵泡的卵泡液，采用ELISA法检测IL-6水平（n=68）。采用非参数检验评估IL-6水平与IVF周期参数之间的关系，采用多变量logistic回归分析评估IL-6水平与临床妊娠之间的关系。结果IL-6与年龄呈正相关（p=0.035）， IL-6与hCG当天雌二醇呈正相关（p=0.011）。经调整分析，体外受精周期患者IL-6水平
Purpose Relationships between follicular fluid levels of IL-6 with ovarian response and clinical pregnancy were evaluated in IVF-ET cycles.Methods Follicular fluid was collected from ovarian follicles >= 14 mm, pooled for each patient, and IL-6 levels were assessed using ELISA (n=68). Relationships between IL-6 levels and IVF cycle parameters were assessed using nonparametric tests, and between IL-6 levels and clinical pregnancy using multivariable logistic regression analyses.Results Significant positive correlations were observed between IL-6 with age (p=0.035), and IL-6 with estradiol on the day of hCG (p=0.011). On adjusted analyses, IVF cycles in patients with IL-6 levels