Lipids, lipoproteins and the risk of benign prostatic hyperplasia in community-dwelling men
Lipids, lipoproteins and the risk of benign prostatic hyperplasia in community-dwelling men
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DOI：
10.1111/j.1464-410x.2007.07332.x
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发表时间：
2008-02-01
影响因子：
4.5
通讯作者：
Barrett-Connor, Elizabeth
中科院分区：
文献类型：
--
作者：
Parsons, J. Kellogg;Bergstrom, Jaclyn;Barrett-Connor, Elizabeth
目的探讨血脂和脂蛋白与社区男性良性前列腺增生症(BPH)的关系。BPH被定义为非癌症的前列腺手术史，或BPH的医学诊断。结果在531名符合条件的受试者中，有259人(48%)报告了BPH，272人(52%)没有BPH，应用Logistic回归模型估计了BPH与空腹血清总胆固醇、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、甘油三酯与高密度脂蛋白的比值有关的优势比。患有BPH的男性平均年龄为75.8(76.1-80.1)岁，而非BPH男性的平均年龄为72.7(72.4-74.0)岁。总胆固醇(P趋势，0.52)、高密度脂蛋白(0.56)、甘油三酯(0.30)或甘油三酯/高密度脂蛋白比值(0.13)与良性前列腺增生症的风险无显著关联。在对糖尿病患者进行的一项子集分析中，那些低密度脂蛋白胆固醇水平最高的三分位数(>；133 mg/dL)与低三分位数(<；110 mg/dL)的人相比，患BPH的可能性高出四倍(优势比4.00，95%可信区间1.27-12.63，P趋势0.02)。这些结果不能用他汀类药物来解释。结论在这些居住在社区的男性中，血清低密度脂蛋白水平较高与糖尿病患者发生BPH的风险较大相关。这些数据表明，低密度脂蛋白胆固醇升高的糖尿病男性患BPH的风险更大。这一观察结果与心脏危险因素参与BPH发病机制的概念是一致的。
OBJECTIVE To examine the associations of serum lipids and lipoproteins with benign prostatic hyperplasia (BPH) in community-dwelling men.SUBJECTS AND METHODS This analysis was conducted within the Rancho Bernardo Study, a prospective, community-based cohort study. BPH was defined as a history of prostate surgery for other than cancer, or a medical diagnosis of BPH. Logistic regression modelling, with adjustments for age and stratification by diabetes diagnosis, was used to estimate the odds ratio (OR) of BPH associated with fasting serum concentrations of total cholesterol, high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol, triglycerides, and the triglyceride to HDL ratio.RESULTS Among 531 eligible participants, 259 (48%) reported BPH and 272 (52%) reported no BPH. Men with BPH, with a mean (range) age of 75.8 (76.1-80.1) years, were older than men without BPH , at 72.7 (72.4-74.0) years. There were no significant associations of total cholesterol (P trend, 0.52), HDL cholesterol (0.56), triglycerides (0.30), or triglyceride to HDL ratio (0.13) with the risk of BPH. In a subset analysis in men with diabetes, those in the highest tertile (> 133 mg/dL) of LDL cholesterol, compared with those in the lowest tertile (< 110 mg/dL), were four times more likely to have BPH (odds ratio 4.00, 95% confidence interval 1.27-12.63, P trend 0.02). These results were not explained by the use of statins.CONCLUSIONS In these community-dwelling men, higher serum LDL was associated with a greater risk of BPH among diabetics. These data suggest that diabetic men with increased LDL cholesterol are at greater risk of BPH. This observation is consistent with the concept that cardiac risk factors are involved with the pathogenesis of BPH.