Does glucagon stimulation predict oral glucose tolerance in patients after simultaneous pancreas-kidney transplantation?
Does glucagon stimulation predict oral glucose tolerance in patients after simultaneous pancreas-kidney transplantation?
复制标题
胰高血糖素刺激是否可以预测胰肾同步移植后患者的口服葡萄糖耐量？
DOI：
10.1097/00007890-200008150-00027
复制
发表时间：
2000
期刊：
影响因子：
6.2
通讯作者：
U. Hopt
中科院分区：
文献类型：
--
作者：
M. Nauck;F. Pfeffer;M. Erb;T. Müller;S. Benz;W. Schmiegel;U. Hopt
背景
外源胰高血糖素能迅速刺激胰岛素分泌。这项测试已被用于评估胰岛素分泌量，这可能预测胰腺移植后患者的口服葡萄糖耐量。
方法
对32例胰肾联合移植受者、10例非糖尿病肾移植受者和9例健康对照受者进行胰高血糖素刺激试验(1 mg静脉注射)。并进行75g口服葡萄糖耐量试验，测定血糖、胰岛素和C-肽谱。
结果
在16例胰岛素反应最低的胰腺移植受者中，有7例口服葡萄糖耐量受损，而16例胰岛素反应较高的患者中有1例发生糖耐量受损(P=0.037)。胰升糖素治疗后胰岛素反应降低与120min血糖浓度显著降低(P=0.043)和口服葡萄糖治疗后积分增量胰岛素反应降低(P=0.006)相关。
结论
在胰腺肾移植受者中，静脉注射胰高血糖素后胰岛素反应降低预示着口服葡萄糖后胰岛素反应降低和口服葡萄糖耐量受损。这项简单的测试可能对胰腺移植受者的随访有帮助。
BACKGROUND
Exogenous glucagon rapidly stimulates insulin secretion. This test has been used to estimate insulin secretory capacity, which may predict oral glucose tolerance in patients after pancreas transplantation.
METHODS
In 32 pancreas-kidney transplant recipients, in 10 nondiabetic kidney transplant recipients, and in 9 healthy control subjects, a glucagon stimulation test (1 mg i.v.) and a 75-g oral glucose tolerance test were performed with determination of glucose, insulin, and C-peptide profiles.
RESULTS
Of 16 pancreas transplant recipients with the lowest insulin responses after glucagon, 7 had an impaired oral glucose tolerance, in contrast to 1 of 16 with high insulin responses (P=0.037). A low insulin response after glucagon was associated with significantly lower 120-min glucose concentrations (P=0.043) and a lower integrated incremental insulin response after oral glucose (P=0.006).
CONCLUSIONS
In pancreas-kidney transplant recipients, a low insulin response after intravenous glucagon predicts a reduced insulin response after oral glucose and an impaired oral glucose tolerance. This simple test may be helpful in the follow-up of pancreas transplant recipients.