Efficient one-pot synthesis of 2,3-dihydropyrimidinthiones via multicomponent coupling of terminal alkynes, elemental sulfur, and carbodiimides.
Efficient one-pot synthesis of 2,3-dihydropyrimidinthiones via multicomponent coupling of terminal alkynes, elemental sulfur, and carbodiimides.
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DOI：
10.1021/ja9069419
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发表时间：
2009-10
影响因子：
15
通讯作者：
Zitao Wang;Yang Wang;Wen‐Xiong Zhang;Z. Hou;Z. Xi
中科院分区：
文献类型：
--
作者：
Zitao Wang;Yang Wang;Wen‐Xiong Zhang;Z. Hou;Z. Xi
首次实现了有机锂促进的多组分反应(MCR)，该反应包括容易获得的末端炔烃、元素硫和碳二亚胺。这种MCR提供了一条合成2，3-二氢嘧啶硫酮的原子经济路线，通过碳二亚胺的有趣和有用的C=N双键裂解和sp(3)C-H键官能化，很难通过其他方法获得这些化合物。
An organolithium-promoted multicomponent reaction (MCR) involving readily available terminal alkynes, elemental sulfur, and carbodiimides has been achieved for the first time. This MCR offers an atom-economic route to 2,3-dihydropyrimidinthiones which are difficult to access by other means via an interesting and useful C=N double bond cleavage and an sp(3) C-H bond functionalization of carbodiimides.