Viral mimicry: common mode of association with HCF By VP16 and the cellular protein LZIP
Viral mimicry: common mode of association with HCF By VP16 and the cellular protein LZIP
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DOI：
10.1101/gad.11.23.3122
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发表时间：
1997-12-01
影响因子：
10.5
通讯作者：
Herr, W
中科院分区：
文献类型：
--
作者：
Freiman, RN;Herr, W
感染人类细胞后，单纯疱疹病毒蛋白 VP16 与内源性细胞增殖因子 HCF 结合。 VP16 还可以与无脊椎动物的 HCF 结合，这表明 VP16 模拟了一种细胞蛋白，其与 HCF 的相互作用是保守的。在这里，我们证明 VP16 模拟人类碱性亮氨酸拉链蛋白 LZIP，通过与 HCF 结合，magi 控制细胞周期进程，VP16 和 LZIP 共享一个四肽 基序-(D)/EHXY-用于与人类 HCF 相关联。 LZIP 相关果蝇蛋白 BBF-2/dCREB-A 含有该 HCF 结合基序，表明 LZIP-HCF 相互作用在后生动物进化过程中得到了保守。
Upon infection of human cells, the herpes simplex virus protein VP16 associates with the endogenous cell-proliferation factor HCF. VP16 can also associate with HCFs from invertebrates, suggesting that VP16 mimics a cellular protein whose interaction with HCF has been conserved, Here, we show that VP16 mimics the human basic leucine-zipper protein LZIP, which, through association with HCF, magi control cell-cycle progression, VP16 and LZIP share a tetrapeptide motif-(D)/EHXY-used to associate with human HCF. The LZIP-related Drosophila protein BBF-2/dCREB-A contains this HCF-binding motif, indicating that the LZIP-HCF interaction has Been conserved during metazoan evolution.