Metabolic syndrome and population attributable risk among HIV/AIDS patients: comparison between NCEP-ATPIII, IDF and AHA/NHLBI definitions
Metabolic syndrome and population attributable risk among HIV/AIDS patients: comparison between NCEP-ATPIII, IDF and AHA/NHLBI definitions
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DOI：
10.1186/1742-6405-9-29
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发表时间：
2012-10-04
影响因子：
2.2
通讯作者：
Fuchs, Sandra C.
中科院分区：
文献类型：
--
作者：
Alencastro, Paulo R.;Wolff, Fernando H.;Fuchs, Sandra C.
背景：代谢综合征（MetS）基于相同的个体成分，但对原始定义进行了多次修改。在本研究中，我们根据不同的标准验证了代谢综合征的患病率，以及各成分对诊断的影响。方法：这项横断面研究招募了来自巴西南部HIV/AIDS参考中心的HIV感染者。代谢综合征是根据国家胆固醇教育计划专家小组对成人高血胆固醇的检测、评估和治疗（NCEP-ATPIII）、国际糖尿病联合会（IDF）和美国心脏协会/国家心肺和血液研究所（AHA/NHLBI）的标准，并使用标准化的问卷调查和血液检测来确定的。结果：1295名hiv感染患者中有1240人入选。男性平均年龄更大，受教育程度更高，自艾滋病诊断以来的时间更短。腰围的人口归因风险（PAR）解释了80%的男性和女性患病率（AHA/NHLBI标准）。根据所有标准，甘油三酯对男性代谢综合征患病率的影响最大，与年龄、肤色和HAART使用无关。结论：在这个HIV感染患者的大样本中，代谢综合征的总体患病率，无论在哪种分类下，都是明显的，AHA/NHLBI定义的患病率最高。
Background: Metabolic Syndrome (MetS) is based on the same individual components, but has received several amendments to the original definition. In this study, we verified the prevalence of metabolic syndrome according to different criteria, and the impact of each component on the diagnostic.Methods: This cross-sectional study enrolled HIV infected patients from a HIV/AIDS reference Center in southern Brazil. Metabolic syndrome was identified according to the National Cholesterol Education Program Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (NCEP-ATPIII), the International Diabetes Federation (IDF) and the American Heart Association/National Heart, Lung and Blood Institute (AHA/NHLBI) criteria, and using a standardized questionnaire and blood testing.Results: A sample of 1240, out of 1295, HIV-infected patients was enrolled. Males were on average older, more educated, and had shorter time since the HIV diagnosis. The population attributable risk (PAR) for waist circumference explained 80% of the prevalence among men and women (AHA/NHLBI criteria). Triglycerides had the highest impact on prevalence of metabolic syndrome according to all criteria, independently of age, skin color and HAART use, among men.Conclusions: In this large sample of HIV infected patients, the overall prevalence of metabolic syndrome, under either classification, was noticeable and the AHA/NHLBI definition accounted for the highest prevalence.