Technical Aspects of Imaging and Transfemoral Arterial Treatment of N1-S1 Tumors in Rats: An Appropriate Model to Test the Biology and Therapeutic Response to Transarterial Treatments of Liver Cancers
Technical Aspects of Imaging and Transfemoral Arterial Treatment of N1-S1 Tumors in Rats: An Appropriate Model to Test the Biology and Therapeutic Response to Transarterial Treatments of Liver Cancers
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DOI：
10.1016/j.jvir.2008.12.408
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发表时间：
2009-03-01
影响因子：
2.9
通讯作者：
Jayaram, Hiremagalur N.
中科院分区：
文献类型：
--
作者：
Ju, Shenghong;McLennan, Gordon;Jayaram, Hiremagalur N.
本研究旨在评估经股动脉肝动脉插管在大鼠中的技术可行性，并描述可用于大鼠肿瘤的成像技术。将106个N1-S1细胞接种于74只大鼠的左叶。17例患者尝试了经股动脉血管造影术。在血管造影术前2周用磁共振成像测量40只动物的肿瘤体积。肿瘤在63只动物中生长。16只大鼠血管造影成功。1周和2周后的平均肿瘤体积分别为0.13 mL和0.9 mL。结论：经股动脉肝动脉插管是可行的。
The present study was undertaken to assess the technical feasibility of transfemoral hepatic artery catheterization in rats and to describe the imaging techniques that can be used on tumors in rats. A total of 106 N1-S1 cells were inoculated into the left lobes of 74 rats. In 17, transfemoral angiography was attempted. Tumor volumes for 2 weeks before angiography were measured with magnetic resonance imaging in 40 animals. Tumors grew in 63 animals. Angiography was successful in 16 rats. Mean tumor volumes were 0.13 mL and 0.9 mL after 1 and 2 weeks, respectively. In conclusion, transfemoral hepatic artery catheterization is feasible in this animal model.