Heat shock factors at a crossroad between stress and development
Heat shock factors at a crossroad between stress and development
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DOI：
10.1196/annals.1391.005
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发表时间：
2007-01-01
期刊：
影响因子：
--
通讯作者：
Sistonen, Lea
中科院分区：
文献类型：
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作者：
Akerfelt, Malin;Trouillet, Diane;Sistonen, Lea
生物体必须能够感知环境的变化并迅速作出反应，以维持体内平衡和生存。诱导热休克蛋白（Hsps）是一种常见的细胞防御机制，可促进细胞在各种应激刺激下的生存。热休克因子（hsf）是热休克因子的转录调节因子，在保护细胞免受蛋白毒性损伤中发挥分子伴侣的作用。哺乳动物有三种不同的hsf，它们被认为在功能上是不同的：HSF1对热休克反应至关重要，也是发育过程所必需的，而HSF2和HSF4对分化和发育很重要。具体来说，HSF2参与皮质发生和精子发生，HSF4是维持感觉器官，如晶状体和嗅觉上皮所需要的。然而，最近的证据表明，HSF1和HSF2在应激条件下调节热休克蛋白表达的功能相互作用。在晶状体形成中，HSF1和HSF4对基因表达有相反的影响。在本章中，我们介绍了哺乳动物hsf作为细胞应激和发育过程调节剂的不同作用。我们强调了不同热休克蛋白之间的相互作用，并讨论了除了经典热休克蛋白外新的靶基因的发现。
Organisms must be able to sense and respond rapidly to changes in their environment in order to maintain homeostasis and survive. Induction of heat shock proteins (Hsps) is a common cellular defense mechanism for promoting survival in response to various stress stimuli. Heat shock factors (HSFs) are transcriptional regulators of Hsps, which function as molecular chaperones in protecting cells against proteotoxic damage. Mammals have three different HSFs that have been considered functionally distinct: HSF1 is essential for the heat shock response and is also required for developmental processes, whereas HSF2 and HSF4 are important for differentiation and development. Specifically, HSF2 is involved in corticogenesis and spermatogenesis, and HSF4 is needed for maintenance of sensory organs, such as the lens and the olfactory epithelium. Recent evidence, however, suggests a functional interplay between HSF1 and HSF2 in the regulation of Hsp expression under stress conditions. In lens formation, HSF1 and HSF4 have been shown to have opposite effects on gene expression. In this chapter, we present the different roles of the mammalian HSFs as regulators of cellular stress and developmental processes. We highlight the interaction between different HSFs and discuss the discoveries of novel target genes in addition to the classical Hsps.