Heterochromatin: new possibilities for the inheritance of structure
Heterochromatin: new possibilities for the inheritance of structure
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DOI：
10.1016/s0959-437x(02)00284-8
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发表时间：
2002-04-01
影响因子：
4
通讯作者：
Elgin, SC
中科院分区：
文献类型：
--
作者：
Grewal, SIS;Elgin, SC
真核生物基因组的重要部分是异色的，主要由重复序列组成，具有与基因沉默相关的独特染色质结构。对包装形式、相关组蛋白修饰和相关异染色质非组蛋白染色体蛋白的新见解提出了一种提供表观遗传标记的机制，该机制允许这种独特的染色质结构在复制后保持并在给定区域内传播。
Significant portions of the eukaryotic genome are heterochromatic, made up largely of repetitious sequences and possessing a distinctive chromatin structure associated with gene silencing. New insights into the form of packaging, the associated histone modifications, and the associated nonhistone chromosomal proteins of heterochromatin have suggested a mechanism for providing an epigenetic mark that allows this distinctive chromatin structure to be maintained following replication and to spread within a given domain.