BRAIN-STEM PROJECTIONS TO THE MAJOR RESPIRATORY NEURON POPULATIONS IN THE MEDULLA OF THE CAT
BRAIN-STEM PROJECTIONS TO THE MAJOR RESPIRATORY NEURON POPULATIONS IN THE MEDULLA OF THE CAT
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DOI：
10.1002/cne.902810107
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发表时间：
1989-03-01
影响因子：
2.5
通讯作者：
FELDMAN, JL
中科院分区：
文献类型：
--
作者：
SMITH, JC;MORRISON, DE;FELDMAN, JL
通过结合辣根过氧化物酶的小麦胚芽凝集素轴突运输，绘制了猫髓质背侧和腹侧呼吸群的输出和传入连接。将小麦胚芽凝集素-山葵过氧化物酶注射到背呼吸组和腹呼吸组的三个主要分支（尾侧、吻侧和Botzinger复核）中，发现这些区域之间存在广泛的相互联系，并与有限数量的其他脑干神经元群存在联系。向背侧和腹侧呼吸群区域输出投射的主要神经元群包括臂旁核复合体（臂旁内侧核、臂旁外侧核和Kolliker-Fuse核）、外侧副巨细胞网状核亚区、外侧和大细胞被盖区亚区、中缝中央下核和锥体后核以及三叉神经感觉核。在延髓吻侧的腹侧表面附近发现了一种以前未发现的神经元群，其向背侧和腹侧呼吸组有广泛的传出投射；我们把这个群称为后梯形核。结果表明，背侧和腹侧呼吸群形成了一个广泛互联的神经元系统，接收来自相同脑干核群的聚合输入，这与背侧和腹侧呼吸群是感觉和运动前呼吸驱动输入整合的主要部位的假设一致。延髓吻侧腹外侧的神经元群投射到背侧和腹侧呼吸群，特别是后梯形核和邻近的外侧副巨细胞网状核亚区，是参与呼吸节律发生或脑干呼吸控制系统的其他关键功能（如颅内化学接受）的候选位点。
Efferent and afferent connections of the dorsal and ventral respiratory groups in the medulla of the cat were mapped by axonal transport of wheat germ agglutinin conjugated to horseradish peroxidase. Injections of wheat germ agglutinin-horseradish peroxidase into the dorsal respiratory group and the three principal subdivisions of the ventral respiratory group (caudal, rostral, and Botzinger Complex) revealed extensive interconnections between these regions and with a limited number of other brainstem neuron populations. Major neuron populations with efferent projections to the regions of the dorsal and ventral respiratory groups include the parabrachial nuclear complex (medial parabrachial, lateral parabrachial, and Kolliker-Fuse nuclei), subregions of the lateral paragigantocellular reticular nucleus, subregions of the lateral and magnocellular tegmental fields, inferior central and postpyramidal nuclei of the raphe, and sensory trigeminal nuclei. A previously unidentified neuron population with extensive efferent projections to the dorsal and ventral respiratory groups was found near the ventral surface of the rostral medulla; we refer to this group as the retrotrapezoid nucleus. The results suggest that the dorsal and ventral respiratory groups form an extensively interconnected neuronal system receiving convergent inputs from the same brainstem nuclear groups, consistent with the hypothesis that the dorsal and ventral groups are primarily sites for integration of sensory and premotor respiratory drive inputs. Neuron populations in the rostral ventrolateral medulla with projections to both the dorsal and ventral respiratory groups, particularly the retrotrapezoid nucleus and neighboring subregions of the lateral paragigantocellular reticular nucleus, are candidate sites for participation in respiratory rhythmogenesis or other critical functions of the brainstem respiratory control system such as intracranial chemoreception.