Comparison of efficacy of cysteamine in depleting prolactin immunoreactivity in different hyperprolactinemic animal models.
Comparison of efficacy of cysteamine in depleting prolactin immunoreactivity in different hyperprolactinemic animal models.
复制标题
半胱胺在不同高催乳素血症动物模型中消耗催乳素免疫反应性的功效比较。
DOI：
10.1016/0024-3205(91)90058-j
复制
发表时间：
1991
期刊：
影响因子：
6.1
通讯作者：
Romano,TM
中科院分区：
文献类型：
--
作者：
Millard,WJ;Romano,TM
我们研究了半胱胺在不同催乳素过多状态下消耗催乳素的能力的影响。在雌激素引发的棕色爱尔兰 ACI 雌性大鼠中，给予亚毒性剂量的半胱胺（75 和 150 mg/kg，皮下注射）以剂量依赖性方式显着降低血清催乳素水平以及垂体催乳素含量。在两种异位催乳素分泌型垂体肿瘤模型（MtTW15 和 7315a）中观察到垂体前叶催乳素水平出现类似的剂量依赖性下降。然而，在仅使用150mg/kg剂量的半胱胺时，在这些相同的荷瘤动物中观察到血清催乳素水平显着降低。有趣的是，每个催乳素分泌肿瘤的催乳素含量虽然因半胱胺给药而降低，但其效果既不是剂量依赖性的，也不像在垂体前叶中观察到的那么显着。这些数据表明半胱胺可以显着降低高催乳素血症中的催乳素浓度。此外，分泌异位催乳素的垂体组织似乎对半胱胺的催乳素消耗作用不太敏感。后一个发现可以部分解释为什么携带异位肿瘤的雌性大鼠的血清催乳素水平没有像雌激素诱导的高催乳素血症动物那样严重降低。
We have examined the effects of cysteamine on its ability to deplete proclatin in various states of hyperproclactineman. Administration of subtoxic dosesof cysteamine (75 and 150 mg/kg,sc) dramatically reduces serum proclatin levels as well as pituitary prolactin content in a dose-dependent manner in estrogen-primed brown IrishACI female rats. A similar dose-dependent decrease in anterior pituitary prolactin levels was observed in two ectopic prolactin secreting pituitary tumor models (MtTW15and 7315a). However, a significant reduction in serum prolactin levels was seen in these sam tumor bearing animals at only the 150 mg/kg dose of cysteamine. Interestingly, the prolactin content of each of the prolactin secreting tumors, although reduced by cysteamine administration, the effect was neither dose-dependent nor as dramatic as that observed in the anterior pituitary gland proper. These data demonstrate that cysteamine can significantly lower prolactin concentrations in hyperprolactinemia. Further, ectopic prolactin secreting pituitary tissue appears less sensitive to the prolactin-depleting effects of cysteamine. This latter finding may explain, in part why serum prolactin levels were not as severely reduced in the eptopic tumor bearing female rats as in estrogen-induced hyperprolactinemic animals.