Factors influencing quality of life in multiple sclerosis patients:: disability, depressive mood, fatigue and sleep quality
Factors influencing quality of life in multiple sclerosis patients:: disability, depressive mood, fatigue and sleep quality
复制标题
DOI：
10.1111/j.1600-0404.2004.00257.x
复制
发表时间：
2004-07-01
影响因子：
3.5
通讯作者：
Zeitlhofer, J
中科院分区：
文献类型：
--
作者：
Lobentanz, IS;Asenbaum, S;Zeitlhofer, J
目的-在一系列的504例多发性硬化症（MS），生活质量（QOL）及其主要的临床和人口统计学决定因素进行了评估，与健康人相比。材料和方法-邮寄问卷与自我完成的残疾（扩展残疾状态量表，EDSS），生活质量（生活质量指数，QLI），抑郁情绪（自评抑郁量表，SDS），疲劳严重程度（疲劳严重程度量表，FSS）和睡眠质量（匹兹堡睡眠质量指数，PSQI）的措施发送到这个样本的MS患者。结果-大多数患者严重残疾;几乎一半的人轻度至重度抑郁，患有睡眠质量下降和/或疲劳。多发性硬化症患者的生活质量指数明显低于健康对照组。EDSS和SDS评分被认为是全球QLI评分的预测因子。关于不同的生活质量指数领域，平均SDS评分仍然预测所有生活质量指数项目，而平均EDSS，PSQI和FSS评分仅预测物理领域。结论-我们的研究清楚地表明，抑郁情绪是影响生活质量的主要因素。残疾状况、疲劳和睡眠质量下降主要影响生活质量的身体领域。
Objectives - In a series of 504 patients with multiple sclerosis (MS), quality of life (QOL) and its main clinical and demographic determinants were assessed in comparison with healthy individuals. Materials and methods - A postal questionnaire with self-completed measures of disability (Expanded Disability Status Scale, EDSS), QOL (Quality of Life Index, QLI), depressive mood (Self-rating Depression Scale, SDS), fatigue severity (Fatigue Severity Scale, FSS) and sleep quality (Pittsburgh Sleep Quality Index, PSQI) was sent to this sample of MS patients. Results - Most patients were severely disabled; almost half were mildly to severely depressed, suffering from reduced sleep quality and/or fatigue. The multiple sclerosis patients had significantly lower QLI scores than healthy controls. EDSS and SDS scores were found to be predictors of global QLI score. Regarding the different QLI domains, mean SDS scores remained predictive for all QLI items, while mean EDSS, PSQI and FSS scores were only predictive for physical domains. Conclusion - Our study clearly demonstrates that depressive mood is the main factor influencing QOL. The disability status, fatigue and reduced sleep quality have an impact mainly on physical domains of life quality.