STUDIES ON THE HOST-MEDIATED ANTITUMOR POLYSACCHARIDES .13. ANTITUMOR-ACTIVITY AND SOME PROPERTIES OF WATER-SOLUBLE POLYSACCHARIDES FROM HIMEMATSUTAKE, THE FRUITING BODY OF AGARICUS-BLAZEI MURILL
STUDIES ON THE HOST-MEDIATED ANTITUMOR POLYSACCHARIDES .13. ANTITUMOR-ACTIVITY AND SOME PROPERTIES OF WATER-SOLUBLE POLYSACCHARIDES FROM HIMEMATSUTAKE, THE FRUITING BODY OF AGARICUS-BLAZEI MURILL
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DOI：
10.1080/00021369.1990.10870406
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发表时间：
1990-11-01
期刊：
影响因子：
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通讯作者：
ASAKURA, A
中科院分区：
文献类型：
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作者：
MIZUNO, T;HAGIWARA, T;ASAKURA, A
Polysaccharides extracted from Himematsutake, the fruiting body of Agaricus blazei Murill with hot water were fractionated and purified by ethanol percipitation, ion-exchange chromatography, gel-filtration, affinity chromatography, etc. A total of 17 polysaccharide samples thus obtained were given an antitumor activity test (Sarcoma 180/mice i.p. p.o. method) and traces of their activities through the fractionation and purification processes were found. FI0-a-.beta., FA-1-a-.alpha., FA-1-a-.beta., and FA-2-b-.beta., were obtained as water soluble polysaccharides fractions having great antitumor activities. Analyses of physico-chemical properties and IR- and NMR-spectra of these active fractions showed that their main components were: FI0-a-.beta., (1 .fwdarw. 6)-; (1 .fwdarw. 3)-.beta.-D-glucan; FA-1-a-.alpha., acidic (1 .fwdarw. 6)-; (1 .fwdarw. 4)-.alpha.-D-glucan; FA-1-a-.beta., acidic (1 .fwdarw. 6)-; (1 .fwdarw. 3)-.alpha.-D-glucan; and FA-2-b-.beta., acidic RNA-protein complex.
