Adverse Drug Events in Adult Patients Leading to Emergency Department Visits
Adverse Drug Events in Adult Patients Leading to Emergency Department Visits
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DOI：
10.1345/aph.1m416
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发表时间：
2010-04-01
影响因子：
2.9
通讯作者：
Gadag, Veeresh
中科院分区：
文献类型：
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作者：
Sikdar, Khokan C.;Alaghehbandan, Reza;Gadag, Veeresh
背景技术背景：不良药物事件（ADE）发生在社区和急诊科（ED）治疗还没有得到很好的研究。目的：确定在加拿大纽芬兰和拉布拉多省的2所大学附属三级保健医院的ED患者中ADE的患病率、严重程度和可预防性。对2005年1月1日至12月31日期间就诊于ED的成人（≥ 18岁）分层随机样本（n = 1458）进行回顾性病历审查。在病历审查之前，通过首先排除明显不是ADE结果的访视来制定样本框架。每例患者的艾德总结最初由2名经过培训的审查员进行审查，以识别可能的ADE。所有符合条件的图表随后由一个临床小组，2名药剂师和2名艾德医生组成的审查，以确定ADE，并确定其严重程度和preventability.RESULTS：1458例患者提出的2个ED，55被确定为有ADE或可能的ADE（PADE）。经样本重量调整后，发现ADE/PADE的患病率为2.4%。患病率随年龄增加而增加（0.7%，18-44岁; 1.9%，45-64岁; 7.8%，65岁），有ADE患者的平均年龄高于无ADE患者（69.9 vs 63.8岁; p
BACKGROUND: Adverse drug events (ADEs) occurring in the community and treated in emergency departments (EDs) have not been well studied.OBJECTIVE: To determine the prevalence, severity, and preventability of ADEs in patients presenting at EDs in 2 university-affiliated tertiary care hospitals in the Canadian province of Newfoundland and Labrador.METHODS: A retrospective chart review was conducted on a stratified random sample (n = 1458) of adults (>= 18 y) who presented to EDs from January 1 to December 31, 2005. Prior to the chart review, the sample frame was developed by first eliminating visits that were clearly not the result of an ADE. The ED summary of each patient was initially reviewed by 2 trained reviewers in order to identify probable ADEs. All eligible charts were subsequently reviewed by a clinical team, consisting of 2 pharmacists and 2 ED physicians, to identify ADEs and determine their severity and preventability.RESULTS: Of the 1458 patients presenting to the 2 EDs, 55 were determined to have an ADE or a possible ADE (PADE). After a sample-weight adjustment, the prevalence of ADEs/PADEs was found to be 2.4%. Prevalence increased with age (0.7%, 18-44 y; 1.9%, 45-64 y; 7.8%, 65 y) and the mean age for patients with ADEs was higher than for those with no ADEs (69.9 vs 63.8 y; p