Altered brain microstructure assessed by diffusion tensor imaging in patients with chronic pancreatitis
Altered brain microstructure assessed by diffusion tensor imaging in patients with chronic pancreatitis
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DOI：
10.1136/gut.2010.236620
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发表时间：
2011-11-01
期刊：
影响因子：
24.5
通讯作者：
Drewes, Asbjorn Mohr
中科院分区：
文献类型：
--
作者：
Frokjaer, Jens Brondum;Olesen, Soren Schou;Drewes, Asbjorn Mohr
目的 越来越多的证据表明，患有疼痛性慢性胰腺炎 (CP) 的患者中枢神经系统存在异常疼痛处理。使用磁共振 (MR) 扩散张量成像，对参与内脏疼痛处理的区域的脑微结构进行了表征，并将这些发现与临床疼痛评分相关。方法使用 3T MR 扫描仪对 23 名 CP 疼痛患者和 14 名对照患者进行研究。评估杏仁核、扣带皮层、岛叶、前额叶皮层和次级感觉皮层的表观扩散系数（ADC）（即水的扩散率）和分数各向异性（FA）（即纤维的组织）值。调查前1周收集每日疼痛评分和简要疼痛量表简表。结果在灰质中，患者杏仁核、扣带皮层、岛叶和前额叶皮层的ADC值升高，而扣带皮层和次级感觉皮层的FA值降低。在白质中，患者的岛叶和前额叶皮质的 ADC 值升高，而岛叶和前额叶皮质的 FA 值降低（所有 p 值）
Objective In patients with painful chronic pancreatitis (CP) there is increasing evidence of abnormal pain processing in the central nervous system. Using magnetic resonance (MR) diffusion tensor imaging, brain microstructure in areas involved in processing of visceral pain was characterised and these findings were correlated to clinical pain scores.Methods 23 patients with CP pain and 14 controls were studied in a 3T MR scanner. Apparent diffusion coefficient (ADC) (ie, diffusivity of water) and fractional anisotropy (FA) (ie, organisation of fibres) values were assessed in the amygdala, cingulate cortex, insula, prefrontal cortex and secondary sensory cortex. Daily pain scores and the Brief Pain Inventory Short Form were collected 1 week before the investigation.Results In grey matter, patients had increased ADC values in amygdala, cingulate cortex, insula and prefrontal cortex, as well as decreased FA values in cingulate cortex and secondary sensory cortex. In white matter, patients had increased ADC values in insula and prefrontal cortex, and decreased FA values in insula and prefrontal cortex (all p values