Genome Rearrangements in mammalian evolution: Lessons from human and mouse genomes
Genome Rearrangements in mammalian evolution: Lessons from human and mouse genomes
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DOI：
10.1101/gr.757503
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发表时间：
2003-01-01
期刊：
影响因子：
7
通讯作者：
Tesler, G
中科院分区：
文献类型：
--
作者：
Pevzner, P;Tesler, G
虽然基因组重排分析是由Dobzhansky和斯图尔特万特在65年前开创的，但我们对产生现有各种基因组结构的重排事件仍然知之甚少。人类和小鼠的基因组序列提供了比以前认为的更大数量的重排的证据，并揭示了哺乳动物进化中以前未知的特征。特别是，他们揭示了需要大量的微重排来解释人类和小鼠序列草案中的差异。在这里，我们描述了一种新的算法，用于构建同线性块，研究安排在人类和小鼠的同线性块，得出一个最吝啬的人类-小鼠重排的情况下，并提供证据，染色体内重排比染色体间重排更频繁。我们的分析是基于人-鼠断点图，它揭示了相关的断点，并允许人们找到一个最吝啬的情况。因为这些图提供了重要的见解重排的情况下，我们引入了一个新的可视化工具，允许查看断点图叠加基因组点图。
Although analysis of genome rearrangements was pioneered by Dobzhansky and Sturtevant 65 years ago, we still know very little about the rearrangement events that produced the existing varieties of genomic architectures. The genomic sequences of human and mouse provide evidence for a larger number of rearrangements than previously thought and shed some light on previously unknown features of mammalian evolution. In particular, they reveal that a large number of microrearrangements is required to explain the differences in draft human and mouse sequences. Here we describe a new algorithm for constructing synteny blocks, study arrangements of synteny blocks in human and mouse, derive a most parsimonious human-mouse rearrangement scenario, and provide evidence that intrachromosomal rearrangements are more frequent than interchromosomal rearrangements. Our analysis is based on the human-mouse breakpoint graph, which reveals related breakpoints and allows one to find a most parsimonious scenario. Because these graphs provide important insights into rearrangement scenarios, we introduce a new visualization tool that allows one to view breakpoint graphs superimposed with genomic dot-plots.