CuCl-catalyzed ortho trifluoromethylation of arenes and heteroarenes with a pivalamido directing group
CuCl-catalyzed ortho trifluoromethylation of arenes and heteroarenes with a pivalamido directing group
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CuCl催化的带有新戊酰胺基导向基团的芳烃和杂芳烃的邻位三氟甲基化
DOI：
10.1039/c3cc41331d
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发表时间：
2013-01-01
影响因子：
4.9
通讯作者：
Xi, Chanjuan
中科院分区：
文献类型：
--
作者：
Cai, Shangjun;Chen, Chao;Xi, Chanjuan
以Togni试剂为CF3源，实现了CuCl催化sp(2) C-H键直接三氟甲基化。该反应实现了区域选择性地将C-H转化为C-CF3的目标，原料既生态又容易获得。
The CuCl catalyzed direct trifluoromethylation of sp(2) C-H bonds has been realized, using the Togni reagent as the CF3 source. This reaction achieves the goal of regio-selectively converting C-H into C-CF3 with ecological and readily available starting materials.