Biogenesis of secretory granules
Biogenesis of secretory granules
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DOI：
10.1016/j.ceb.2006.06.010
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发表时间：
2006-08-01
影响因子：
7.5
通讯作者：
Solimena, Michele
中科院分区：
文献类型：
--
作者：
Borgonovo, Barbara;Ouwendijk, Joke;Solimena, Michele
神经内分泌细胞的分泌颗粒储存和释放肽激素和神经肽以响应各种刺激。从高尔基复合体生成颗粒涉及货物蛋白的聚集以及它们与非调节分泌分子的分选。最近对缺乏单个颗粒成分的基因敲除小鼠的研究结果挑战了存在这些细胞器组装的“必需”蛋白质的假设，而对聚嘧啶束结合蛋白和 ICA512/IA-2 的研究提供了对调节与刺激和分泌活性相关的颗粒产生的机制的见解。
Secretory granules of neuroendocrine cells store and release peptide hormones and neuropeptides in response to various stimuli. Generation of granules from the Golgi complex involves the aggregation of cargo proteins and their sorting from non-regulated secretory molecules. Recent findings on knockout mice lacking individual granule constituents have challenged the hypothesis that an 'essential' protein for the assembly of these organelles exists, while studies on polypyrimidine tract-binding protein and ICA512/IA-2 have provided insight into the mechanisms for adjusting granule production in relation to stimulation and secretory activity.