Control of C-elegans hermaphrodite gonad size and shape by vab-3/Pax6-mediated regulation of integrin receptors
Control of C-elegans hermaphrodite gonad size and shape by vab-3/Pax6-mediated regulation of integrin receptors
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DOI：
10.1101/gad.1534807
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发表时间：
2007-07-01
影响因子：
10.5
通讯作者：
Schwarzbauer, Jean E.
中科院分区：
文献类型：
--
作者：
Meighan, Christopher M.;Schwarzbauer, Jean E.
细胞外基质的整合素受体对细胞运动至关重要，但决定何时停止的信号尚不清楚。对秀丽隐杆线虫性腺发生过程中远端尖端细胞（DTC）迁移的分析揭示了转录因子vab-3/Pax 6在调节α整合素基因ina-1和pat-2中的重要性。利用vab-3突变体，我们表明，下调的ina-1是必要的DTC迁移停止和上调的pat-2所需的方向性。这些结果证明了每种整联蛋白在迁移中的共同但不同的作用。值得注意的是，迁移终止的转录控制为调节形态发生和器官大小提供了一种新的机制。
Integrin receptors for extracellular matrix are critical for cell motility, but the signals that determine when to stop are not known. Analysis of distal tip cell (DTC) migration during gonadogenesis in Caenorhabditis elegans has revealed the importance of transcription factor vab-3/Pax6 in regulating the alpha integrin genes, ina-1 and pat-2. Utilizing vab-3 mutants, we show that the down-regulation of ina-1 is necessary for DTC migration cessation and the up-regulation of pat-2 is required for directionality. These results demonstrate concomitant, but distinct roles in migration for each integrin. Notably, transcriptional control of migration termination provides a new mechanism for regulation of morphogenesis and organ size.