Endocytosis and Signaling during Development
Endocytosis and Signaling during Development
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DOI：
10.1101/cshperspect.a017020
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发表时间：
2014-03-01
影响因子：
7.2
通讯作者：
Brand, Michael
中科院分区：
文献类型：
--
作者：
Boekel, Christian;Brand, Michael
多细胞生物的发育依赖于细胞间通讯事件的复杂编排，这些事件使胚胎形成模式并协调组织和器官的形成。因此，发育生物学，特别是使用遗传模式生物，对相关信号转导级联的发现和功能解剖做出了重大贡献，这并不奇怪。与此同时，生物物理学、生物化学和细胞生物学方法为我们提供了对潜在细胞生物学机制的见解。在这里，我们专注于如何内吞运输的信号成分（e。例如，在一个实施例中，配体或受体）控制发育信号的产生、传播、调节、接收和解释。一个全面的枚举的内吞作用和信号转导之间的联系将超出这一审查的限制。相反，我们将使用来自不同发育途径的例子来概念性地说明胞内吞过程在细胞间信号传导的关键步骤中提供的各种功能。
The development of multicellular organisms relies on an intricate choreography of intercellular communication events that pattern the embryo and coordinate the formation of tissues and organs. It is therefore not surprising that developmental biology, especially using genetic model organisms, has contributed significantly to the discovery and functional dissection of the associated signal-transduction cascades. At the same time, biophysical, biochemical, and cell biological approaches have provided us with insights into the underlying cell biological machinery. Here we focus on how endocytic trafficking of signaling components (e. g., ligands or receptors) controls the generation, propagation, modulation, reception, and interpretation of developmental signals. A comprehensive enumeration of the links between endocytosis and signal transduction would exceed the limits of this review. We will instead use examples from different developmental pathways to conceptually illustrate the various functions provided by endocytic processes during key steps of intercellular signaling.