Successful Immunosuppressive Therapy With Cyclosporine A for Posthepatitis B-Cell Deficiency With Activated Cytoplasmic Interferon-γ—Positive T-Lymphocytes
Successful Immunosuppressive Therapy With Cyclosporine A for Posthepatitis B-Cell Deficiency With Activated Cytoplasmic Interferon-γ—Positive T-Lymphocytes
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使用环孢菌素 A 成功治疗肝炎后 B 细胞缺陷（活化细胞质干扰素-γ - 阳性 T 淋巴细胞）
DOI：
10.1007/bf02982043
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发表时间：
2002
影响因子：
2.1
通讯作者：
Masayuki Kobayashi
中科院分区：
文献类型：
--
作者：
H. Otsubo;K. Kaito;Y. Ogasawara;T. Shimada;N. Usui;Masayuki Kobayashi
我们描述了一个病人的短暂消失B细胞，低丙种球蛋白血症，和轻度全血细胞减少急性肝炎后。HLA-DR+ CD 8+和细胞内IFN-γ+/IL-4-细胞水平均显著升高，导致细胞毒性T细胞（TC）1/TC 2和辅助性T细胞（Th）1/Th 2比值升高。免疫抑制治疗后，环孢素A，这些参数的T细胞活化明显下降，血液学恢复，包括增加B淋巴细胞和免疫球蛋白浓度，获得。这些结果表明，活化的T细胞抑制了B细胞。一些常见的可变免疫缺陷患者表现出类似的T细胞功能激活，目前的研究结果表明，免疫抑制治疗的可能性，这样的患者。
We describe a patient with transient disappearance of B-cells, hypogammaglobulinemia, and mild pancytopenia after acute hepatitis. Both HLA-DR+CD8+ and intracellular interferon-γ+/interleukin-4- cell levels were markedly increased, resulting in an increase in the cytotoxic T-cell (TC)1/TC2 and helper T-cell (Th)1/Th2 ratios. After immunosuppressive therapy with cyclosporine A, these parameters of T-cell activation were clearly decreased, and hematologic recovery, including an increase in B-lymphocytes and immunoglobulin concentration, was obtained. These results suggest that there had been suppression of B-cells by activated T-cells. Some patients with common variable immunodeficiency show similar activation of T-cell function, and the present findings suggest the possibility of immunosuppressive therapy for such patients.