Flueggines A and B, two new dimeric indolizidine alkaloids from Flueggea virosa.
Flueggines A and B, two new dimeric indolizidine alkaloids from Flueggea virosa.
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DOI：
10.1021/ol201410z
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发表时间：
2011-07
期刊：
影响因子：
5.2
通讯作者：
Bingxin Zhao;Ying Wang;Dong-Mei Zhang;Renliang Jiang;Guo-Cai Wang;Jun-Min Shi;Xiao‐Jun Huang;
中科院分区：
文献类型：
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作者：
Bingxin Zhao;Ying Wang;Dong-Mei Zhang;Renliang Jiang;Guo-Cai Wang;Jun-Min Shi;Xiao‐Jun Huang;
从 Flueggea virosa 的枝条和叶子中分离出两种前所未有的 C,C 连接二聚吲哚里西啶生物碱，flueggines A (1) 和 B (2)。通过NMR、单晶X射线衍射和CD分析阐明了结构和绝对构型。化合物 1 是带有异恶唑烷环的叶底生物碱的第一个例子，还提出了其合理的生物发生途径。化合物 2 对 MCF-7 和 MDA-MB-231 人乳腺癌细胞表现出生长抑制活性。
Two unprecedented C,C-linked dimeric indolizidine alkaloids, flueggines A (1) and B (2), were isolated from the twigs and leaves of Flueggea virosa. The structures and absolute configurations were elucidated by means of NMR, single-crystal X-ray diffraction, and CD analyses. Compound 1 is the first example of Securinega alkaloids bearing an isoxazolidine ring, the plausible biogenetic pathway of which is also proposed. Compound 2 exhibited growth inhibitory activity against MCF-7 and MDA-MB-231 human breast cancer cells.