Diurnal axial length fluctuations in human eyes
Diurnal axial length fluctuations in human eyes
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DOI：
10.1167/iovs.03-0294
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发表时间：
2004-01-01
影响因子：
4.4
通讯作者：
Schmid, G
中科院分区：
文献类型：
--
作者：
Stone, RA;Quinn, GE;Schmid, G
目的.这项研究寻求在人类受试者的眼睛长度的昼夜变化，类似于那些报道，实验室动物。17名受试者，年龄7 - 53岁（中位数16），平均等效球镜屈光不正-0.68 D（范围，-3.00至+1.00 D），在7 AM至次日1 AM之间多次使用部分相干干涉术（PCI）（一种高精度非接触方法）进行眼轴长度测量。其中10名受试者在两天或两天以上的时间内获得了昼夜轴长测量结果。在至少1天期间，15名受试者显示出具有统计学显著性（ANOVA，P < 0.05）的眼轴长度的昼夜波动，幅度通常在15和40 μ m之间。从符合正弦曲线使用统计标准的昼夜跟踪，波动的平均周期为21.6 +/- 4.33小时（SD），平均振幅为27.1 +/- 11.9妈妈（SD;范围，12.8-41.4妈妈），最大轴长往往发生在中午。每天多次测量的每个受试者至少在1天内显示轴长波动，但昼夜变化存在差异：最值得注意的是，每天有4名受试者显示轴长波动;在其他受试者中，每个测试日均未观察到波动。人眼的眼轴长度经历昼夜波动，其模式表明中午时的最大眼轴长度。根据重复测量，这些每日波动可能不会在所有受试者中定期出现，这表明可能存在必须定义的生理影响。
PURPOSE. This study sought diurnal variations of eye length in human subjects, analogous to those reported in, laboratory animals.METHODS. Seventeen subjects, ages 7 to 53 (median 16) years and mean spherical equivalent refractive error - 0.68 D (range, -3.00 to +1.00 D), underwent axial length measurements at multiple times during the day between 7 AM and 1 AM the following day, using partial coherence interferometry (PCI), a highly precise, noncontact method. Diurnal axial length measurements were obtained on two or more days in 10 of these subjects.RESULTS. During at least I day, 15 subjects showed a statistically significant (ANOVA, P < 0.05) diurnal fluctuation of axial length, with a magnitude generally between 15 and 40 mum. From the diurnal tracings that fit a sine curve using statistical criteria, the mean period of fluctuation was 21.6 +/- 4.33 hours (SD), the mean amplitude was 27.1 +/- 11.9 mum (SD; range, 12.8-41.4 mum), and the maximum axial length tended to occur at midday. Each of the subjects with multiple daily measurements showed axial length fluctuations on at least 1 day, but there were day-to-day differences in the diurnal variations: most notably, four subjects showed axial length fluctuations on each day; in others, the fluctuations were not observed on each testing day.CONCLUSIONS. The human eye undergoes diurnal fluctuations in axial length, with a pattern suggesting maximum axial length at midday. Based on repeated measurements, these daily fluctuations may not appear regularly in all subjects, suggesting the possibility of physiologic influences that must be defined.