Homeostasis and anergy of CD4+CD25+ suppressor T cells in vivo
Homeostasis and anergy of CD4+CD25+ suppressor T cells in vivo
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DOI：
10.1038/ni743
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发表时间：
2002-01-01
影响因子：
30.5
通讯作者：
Rudensky, A
中科院分区：
文献类型：
--
作者：
Gavin, MA;Clarke, SR;Rudensky, A
CD4(+)CD25(+) suppressor T (T-5) cells play a critical role in the maintenance of peripheral tolerance. We examined here proliferative and functional responses as well as differential gene expression in T-s cells. We found that Ts cells were hyporesponsive to antigenic stimuli in vivo and unable to flux Ca2+ upon T cell receptor (TCR) engagement. However, T-s cells were not impaired in their proliferative response to lymphopenia, which was dependent on major histocompatibility complex class 11 expression. Homeostatic proliferation did not abolish T-s cell anergy; rather, it substantially augmented T-s cell function. DNA array analyses identified genes that may inhibit responsiveness at a number of levels in multiple signaling cascades in T-s cells, as well as several anti-apoptotic genes that may mediate their survival.
