Pulmonary function changes in long-term survivors of bone marrow transplantation
Pulmonary function changes in long-term survivors of bone marrow transplantation
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DOI：
10.1016/s0360-3016(96)00123-x
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发表时间：
1996-08-01
影响因子：
7
通讯作者：
Lipchik, RJ
中科院分区：
文献类型：
--
作者：
Gore, EM;Lawton, CA;Lipchik, RJ
目的：本研究旨在评估骨髓移植（BMT）患者的长期肺功能变化，评估其临床意义，并确定影响这些变化的因素。方法与材料：对1985 ~ 1991年间111例行肺移植术的成人患者进行肺功能测试（PFT）前后的评价。评估1 s用力呼气量（FEV(1)）、用力肺活量（FVC）、弥散量（DLCO）、总肺活量（TLC）。103例（92.8%）患者接受了9等份总剂量为14 Gy的全身照射（TBI）。肺剂量限制在
Purpose: This study was undertaken to evaluate long-term pulmonary function changes in patients undergoing bone marrow transplantation (BMT), to assess their clinical significance, and to identify factors influencing these changes.Methods and Materials: Pulmonary function tests (PFT) were evaluated before and after BMT in 111 adult patients undergoing BMT between 1985 and 1991. Forced expiratory volume at 1 s (FEV(1)), forced vital capacity (FVC), diffusing capacity (DLCO), and total lung capacity (TLC) were evaluated. One hundred and three patients (92.8%) received total body irradiation (TBI) to a total dose of 14 Gy in nine equal fractions. The lung dose was restricted to