Neonatal Early-Onset Sepsis.
Neonatal Early-Onset Sepsis.
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新生儿早发型败血症。
DOI：
10.1542/neo.23-10-e756
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发表时间：
2022-11-01
期刊：
影响因子：
--
通讯作者：
Puopolo, Karen M
中科院分区：
文献类型：
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作者：
Flannery, Dustin D;Puopolo, Karen M
早发性脓毒症（EOS）是新生儿发病和死亡的重要原因，特别是早产儿。EOS的流行病学随着时间的推移而发生变化。在这里，我们重点介绍了新生儿EOS流行病学的最新数据，包括发病率，微生物学，风险因素和相关结果，重点关注在高收入国家出生的婴儿在出生住院期间。我们讨论了EOS的风险评估方法，总结了国家指南，并比较了足月儿和早产儿方法之间的主要差异。最后，我们分析了EOS病原体的当代抗生素耐药性数据，以提供EOS的最佳经验性治疗。
Early-onset sepsis (EOS) is a significant cause of morbidity and mortality among newborn infants, particularly among those born premature. The epidemiology of EOS is changing over time. Here, we highlight the most contemporary data informing the epidemiology of neonatal EOS, including incidence, microbiology, risk factors, and associated outcomes, with a focus on infants born in high-income countries during their birth hospitalization. We discuss approaches to risk assessment for EOS, summarizing national guidelines and comparing key differences between approaches for term and preterm infants. Lastly, we analyze contemporary antibiotic resistance data for EOS pathogens to inform optimal empiric treatment for EOS.