Regulation of the cell cycle by calcium and calmodulin.
Regulation of the cell cycle by calcium and calmodulin.
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DOI：
10.1210/edrv-14-1-40
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发表时间：
1993-02
影响因子：
20.3
通讯作者：
Kun Ping Lu;A. R. Means
中科院分区：
文献类型：
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作者：
Kun Ping Lu;A. R. Means
I.为了繁殖和繁殖，每个细胞都必须在其生命周期的某个时间执行一系列有序的事件，通常称为细胞周期。细胞周期首先被认为是由有丝分裂和间期，从形态学分析确定。随着新技术的发展，DNA合成的一个时期，S期，被检测到;这是从以前的有丝分裂的“间隙”，G1期，从随后的有丝分裂的另一个“间隙”，G2期（图1）。G1期是决定期，其中细胞要么承诺进行另一轮DNA合成并继续循环，要么退出细胞周期以进入通常称为G 0的静止状态。G 0期细胞在加入适当的促分裂原后，要么终末分化，要么恢复增殖（图1）。当DNA合成完成时，细胞通常进行有丝分裂。这一系列事件的调节是内分泌学家的主要兴趣。
I. Introduction IN ORDER to reproduce and multiply, every cell must execute an orderly series of events, generally called the cell cycle, at some time during its life span. The cell cycle was first thought to consist of mitosis and interphase as determined from morphological analysis. As new techniques were developed, a period of DNA synthesis, the S phase, was detected; this was temporally separated from the previous mitosis by a “gap,” the G1 phase, and from the subsequent mitosis by another “gap,” the G2 phase (Fig. 1). The G1 phase is the decision phase in which cells either commit to undergo another round of DNA synthesis and continue to cycle or to exit the cell cycle to enter a quiescent state frequently referred to as G0. Cells in the G0 phase either terminally differentiate or resume proliferation upon addition of an appropriate mitogen (Fig. 1). When DNA synthesis is completed, cells normally proceed to mitosis. The regulation of this series of events is of primary interest to the endocrinologis...