Candida albicans-epithelial interactions and pathogenicity mechanisms: scratching the surface.
Candida albicans-epithelial interactions and pathogenicity mechanisms: scratching the surface.
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DOI：
10.1080/21505594.2015.1012981
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发表时间：
2015
期刊：
影响因子：
5.2
通讯作者：
Naglik JR
中科院分区：
文献类型：
--
作者：
Moyes DL;Richardson JP;Naglik JR
直到最近，上皮细胞在宿主对微生物的反应中一直被忽视。然而，在过去的十年中，随着越来越多的研究强调了这些细胞在我们与微生物群和病原体的许多相互作用中发挥的关键作用，这种观点在很大程度上被推翻了。这些细胞与白色念珠菌的相互作用不仅在宿主反应中至关重要，而且在真菌细胞反应中也至关重要，调节真菌形态和基因表达谱。在这篇综述中，我们将探讨白色念珠菌与上皮细胞之间的相互作用，并讨论这些相互作用如何影响我们与这种真菌的关系。
Until recently, epithelial cells have been a largely ignored component of host responses to microbes. However, this has been largely overturned over the last decade as an ever increasing number of studies have highlighted the key role that these cells play in many of our interactions with our microbiota and pathogens. Interactions of these cells with Candida albicans have been shown to be critical not just in host responses, but also in fungal cell responses, regulating fungal morphology and gene expression profile. In this review, we will explore the interactions between C. albicans and epithelial cells, and discuss how these interactions affect our relationship with this fungus.