Increased circulating endothelial cells in acute heart failure: Comparison with von Willebrand factor and soluble E-selectin
Increased circulating endothelial cells in acute heart failure: Comparison with von Willebrand factor and soluble E-selectin
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DOI：
10.1016/j.ejheart.2005.06.010
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发表时间：
2006-03-01
影响因子：
18.2
通讯作者：
Blann, AD
中科院分区：
文献类型：
--
作者：
Chong, AY;Lip, GYH;Blann, AD
后面一圈：外周血中的循环内皮细胞（CEC）可能代表内皮细胞损伤的最直接证据，在心肌梗塞、不稳定型心绞痛和严重肢体缺血中增加。由于慢性心力衰竭也与内皮异常相关，我们假设CEC在急性心力衰竭中升高，并且它们与内皮扰动的血浆指数相关，即血管性血友病因子（vWf）和可溶性E-选择素。我们研究了30例急性心力衰竭患者（在急诊入院24 It内静脉注射），30例慢性稳定性心力衰竭患者（门诊静脉注射，所有患者均为窦性心律，射血分数
Back round: Circulating endothelial cells (CECs) in the peripheral blood, probably representing the most direct evidence of endothelial cell g damage, are increased in myocardial infarction, unstable angina and critical limb ischaemia. As chronic heart failure is also associated with endothelial abnormalities, we hypothesised that CECs are raised in acute heart failure and that they would correlate with plasma indices of endothelial perturbation, that is, von Willebrand factor (vWf) and soluble E-selectin.Methods: We studied 30 patients with acute heart failure (venesected within 24 It of emergency hospital admission), 30 patients with chronic stable heart failure (venesected as out-patients, all patients in sinus rhythm with ejection fraction