Barrel cortex critical period plasticity is independent of changes in NMDA receptor subunit composition
Barrel cortex critical period plasticity is independent of changes in NMDA receptor subunit composition
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DOI：
10.1016/s0896-6273(01)00501-3
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发表时间：
2001-11-20
期刊：
影响因子：
16.2
通讯作者：
Crair, MC
中科院分区：
文献类型：
--
作者：
Lu, HC;Gonzalez, E;Crair, MC
发育过程中NMDAR亚单位组成和表达的调节被认为是控制丘脑皮质传入神经、分离和可塑性的过程。小鼠丘脑皮质突触的可塑性依赖于含有NR2B亚单位的NMDAR，NR2B亚单位是可塑性的“关键时期”窗口中的主要形式。在关键期接近尾声时，NR2A亚单位的贡献逐渐增加，这与NMDAR介导的电流动力学的变化平行发生。然而，在NR2A基因敲除小鼠中，没有出现临界期的延长，尽管在临界期结束后，NMDA亚基组成和电流动力学仍然不成熟。这些数据表明，NMDAR亚单位组成的调节对于关闭小鼠躯体感觉桶皮质的关键期可塑性窗口并不是必需的。
The regulation of NMDA receptor (NMDAR) subunit composition and expression during development is thought to control the process of thalamocortical afferent innervation, segregation, and plasticity. Thalamocortical synaptic plasticity in the mouse is dependent on NMDARs containing the NR2B subunit, which are the dominant form during the "critical period" window for plasticity. Near the end of the critical period there is a gradual increase in the contribution of NR2A subunits that happens in parallel to changes in NMDAR-mediated current kinetics. However, no extension of the critical period occurs in NR2A knockout mice, despite the fact that NMDA subunit composition and current kinetics remain immature past the end of the critical period. These data suggest that regulation of NMDAR subunit composition is not essential for closing the critical period plasticity window in mouse somatosensory barrel cortex.