Hypoglycemic effect of Cecropia obtusifolia on streptozotocin diabetic rats
Hypoglycemic effect of Cecropia obtusifolia on streptozotocin diabetic rats
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DOI：
10.1016/s0378-8741(01)00335-x
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发表时间：
2001-12-01
影响因子：
5.4
通讯作者：
Wiedenfeld, H
中科院分区：
文献类型：
--
作者：
Andrade-Cetto, A;Wiedenfeld, H
采用链脲佐菌素诱导的糖尿病大鼠模型，研究了天麻叶水提物和丁醇提取物对糖尿病大鼠的降血糖作用。单次灌胃90和150 mg/kg的水提取物和9和15 mg/kg的丁醇提取物可显著降低糖尿病大鼠的血糖水平(P<；0.05)。以格列本脲为参照物，在3 mg/kg剂量下表现出与受试提取物相似的降血糖作用。黄酮异胡萝卜素和3-咖啡酰奎宁酸(绿原酸)是该植物的重要成分，也是两种提取物中的主要成分。(C)2001爱思唯尔爱尔兰科学有限公司。保留所有权利。
The hypoglycemic effects of water and butanolic extracts prepared from leaves of Cecropia obtusifolia (Cecropiaceae) were examined in streptozotocin induced diabetic rats. A single oral administration of a water extract at doses of 90 and 150 mg/kg and of a butanol extract at doses of 9 and 15 mg/kg significantly (P < 0.05) lowered the plasma glucose levels in diabetic rats after 3 h administration. Glibenclamide was used as reference and showed similar hypoglycemic effect to the tested extracts at a dose of 3 mg/kg. The flavone, isoorientin and 3-caffeoylquinic acid (chlorogenic acid), were isolated as the important constituents of the plant and were identified as the main constituents in both extracts, too. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.