Changes in the use of antimicrobials and the effects on productivity of swine farms in Denmark
Changes in the use of antimicrobials and the effects on productivity of swine farms in Denmark
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DOI：
10.2460/ajvr.71.7.726
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发表时间：
2010-07-01
影响因子：
1
通讯作者：
Wegener, Henrik C.
中科院分区：
文献类型：
--
作者：
Aarestrup, Frank M.;Jensen, Vibeke F.;Wegener, Henrik C.
评价1992年至2008年期间丹麦猪场抗菌剂消耗量和生产率的变化。样本群体-所有丹麦猪场的抗菌剂消耗量数据和丹麦猪群的代表性样本的生产率数据。程序-根据规范抗菌剂消耗的政策，确定和评价1992年至2008年丹麦猪场的抗菌剂消耗量，疾病模式和生产力数据的变化。生产力数据的趋势分析之前和之后，禁止使用抗菌生长促进剂（AGPs.Results-Antimicrobial消费量达到峰值100 mg/kg的猪在1992年生产，1999年下降到31 mg/kg，并在2008年增加到49 mg/kg。变化的关键因素是1994年禁止抗菌剂亚治疗使用的法规和兽医从处方和销售抗菌剂中获利以及2000年1月终止使用AGP。生猪产量从1840万头增加到2.71亿头，平均每头母猪每年出栏的生猪数量从1992年的21头增加到2007年的25头。但1992年和2008年断奶和育肥猪的死亡率相似。结论和临床意义-从1992年到2008年，丹麦生产的每公斤猪的抗菌药物消耗量下降了> 50%。此外，生产力有所提高，表明禁止使用AGP不会对长期猪生产力产生负面影响。(Am J Vet Res 2010;71：726-733）
Objective-To evaluate changes in antimicrobial consumption and productivity by Danish swine farms during 1992 to 2008.Sample Population-All Danish swine farms for antimicrobial consumption data and a representative sample of Danish swine herds for productivity data.Procedures-Antimicrobial consumption by Danish swine farms from 1992 to 2008 was determined and evaluated in light of policies to regulate antimicrobial consumption, changes in disease patterns, and productivity data. Trend analyses of productivity data were conducted before and after a ban on use of antimicrobial growth promoters (AGPs).Results-Antimicrobial consumption peaked at 100 mg/kg of swine produced in 1992, decreased to 31 mg/kg in 1999, and increased to 49 mg/kg in 2008. Key factors for changes were regulations banning subtherapeutic use of antimicrobials and veterinary profits from the prescription and sale of antimicrobials in 1994 and termination of AGP use by January 2000. Pig production increased from 18.4 to 271 million pigs, and the mean number of pigs per sow per year raised for slaughter increased from 21 in 1992 to 25 in 2007 Average daily gain for weaning (35 kg) pigs was higher in 2008 than in 1992, but mortality rates for weaning and finishing pigs were similar in 1992 and 2008.Conclusions and Clinical Relevance-From 1992 to 2008, antimicrobial consumption per kilogram of pig produced in Denmark decreased by > 50%. Furthermore, there was improvement in productivity, suggesting that long-term swine productivity was not negatively impacted by a ban on AGP use. (Am J Vet Res 2010;71:726-733)