Diffusion tensor MRI-based estimation of the influence of brain tissue anisotropy on the effects of transcranial magnetic stimulation
Diffusion tensor MRI-based estimation of the influence of brain tissue anisotropy on the effects of transcranial magnetic stimulation
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DOI：
10.1016/j.neuroimage.2007.03.062
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发表时间：
2007-07-15
期刊：
影响因子：
5.7
通讯作者：
Walsh, V.
中科院分区：
文献类型：
--
作者：
De Lucia, M.;Parker, G. J. M.;Walsh, V.
我们评估和讨论了纤维各向异性在评估经颅磁刺激(TMS)对人脑影响方面的相关性。对包含扩散张量成像(DTI)得到的各向异性电导率信息的头部三维模型进行了有限元模拟，结果表明各向异性对主激活轨迹的位置和强度的影响都很小。它对感应电场的空间分布有相当大的影响，产生的差异约为最大感应电场的10%。此外，当我们在计算中考虑纤维的各向异性时，磁刺激的影响面积比在各向同性模型中略大。我们还发现，在各向异性模型中观察到的感应场并不总是与局部纤维取向一致，而是遵循特定的平行模式。这些发现将有助于改进对磁刺激涉及的区域的估计。(C)2007 Elsevier Inc.保留所有权利。
We evaluate and discuss the relevance of fiber anisotropy in estimating the effect of transcranial magnetic stimulation (TMS) on the human brain. Finite element simulations were carried out on a three-dimensional model of the head that included anisotropic conductivity information derived from diffusion tensor imaging (DTI).The results show that anisotropy has minor effects both on the position of the main locus of activation and on its intensity. It has considerably more effect on the spatial distribution of the induced electric field, yielding differences of the order of 10% of the maximum induced field. Moreover the area affected by magnetic stimulation is slightly larger when we include fiber anisotropy in the calculations than in an isotropic model. We also show that the induced field observed in the anisotropic model does not always align with the local fiber orientation but rather follows specific patterns of parallelity.These findings will help to improve the estimation of the areas involved in magnetic stimulation. (C) 2007 Elsevier Inc. All rights reserved.