Immune deficiency and autoimmunity
Immune deficiency and autoimmunity
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DOI：
10.1016/s1568-9972(03)00052-1
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发表时间：
2003-10-01
影响因子：
13.6
通讯作者：
Etzioni, A
中科院分区：
文献类型：
--
作者：
Etzioni, A
免疫缺陷和自身免疫现象可能同时发生在同一个人身上。许多免疫缺陷综合征，主要是体液缺陷，与自身免疫性疾病有关。血液学表现，例如血小板减少症和溶血性贫血，是最常见的表现，但也描述了许多其他自身免疫介导的病症。由于免疫系统消除发病机制的能力固有缺陷，持续的抗原刺激是导致原发性免疫缺陷患者发生自身免疫的主要原因。本综述将讨论导致自身免疫表现发生率增加的其他因素。静脉注射丙种球蛋白治疗可以改善自身免疫性疾病，骨髓移植可以治愈这两种疾病。 (C) 2003 Elsevier Science B.V. 保留所有权利。
Immunodeficiency and autoimmune phenomena may occur concomitantly in the same individual. Many immune deficiency syndromes, mainly humoral defects, are associated with autoimmune disorders. Hematological manifestations, such as thrombocytopenia and hemolytic anemia, are the most common presentation, but many other autoimmune mediated conditions have also been described. Persistent antigen stimulation, due to an inherently defective immune system ability to eradicate pathogenesis is the primary cause leading to autoimmunity in patients with primary immunodeficiency states. Other factors leading to the increase incidence of autoimmune manifestion will be discussed in the present review. Treatment with intravenous gammagluobuilin may ameliorate the autoimmune disorder and bone marrow transplantation can cure both conditions. (C) 2003 Elsevier Science B.V. All rights reserved.