Early recovery following new onset anosmia during the COVID-19 pandemic - an observational cohort study
Early recovery following new onset anosmia during the COVID-19 pandemic - an observational cohort study
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DOI：
10.1186/s40463-020-00423-8
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发表时间：
2020-05-04
影响因子：
3.4
通讯作者：
Kumar, B. Nirmal
中科院分区：
文献类型：
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作者：
Hopkins, Claire;Surda, Pavol;Kumar, B. Nirmal
背景快速发展的证据表明，嗅觉和味觉障碍是COVID-19感染的常见症状。到目前为止，还没有关于持续时间和回收率的报告。我们着手对COVID-19疫情期间报告新发嗅觉和味觉障碍的患者进行评估，并报告早期康复率。方法对2019冠状病毒病大流行期间报告自我诊断为新发嗅觉和味觉障碍的患者进行在线调查，并随访1周。结果382例患者完成了首次和随访调查。在完成第一次调查时，86.4%的人报告完全嗅觉丧失，另有11.5%的人报告非常严重的嗅觉丧失。在1周后的随访中，嗅觉丧失严重程度的自我评定已经有显著改善。80.1%的患者报告随访时严重程度评分降低，17.6%无变化，1.9%恶化。11.5%的患者在随访时已经报告完全消退，而17.3%的患者报告持续完全丧失嗅觉，报告的持续时间为1至4周以上。这反映在两次调查之间的总体累积改善率为79%。结论对越来越多的证据基础的审查支持我们的队列可能遭受嗅觉丧失作为COVID-19感染的一部分。虽然早期康复率令人鼓舞，但长期康复率仍需进一步调查，而且由于大流行病，病毒感染后持续性丧失的患者可能会增加。我们进一步呼吁将嗅觉丧失作为COVID-19感染的标志。
Background A rapidly evolving evidence suggests that smell and taste disturbance are common symptoms in COVID-19 infection. As yet there are no reports on duration and recovery rates. We set out to characterise patients reporting new onset smell and taste disturbance during the COVID-19 pandemic and report on early recovery rates. Methods Online Survey of patients reporting self-diagnosed new onset smell and taste disturbance during the COVID-19 pandemic, with 1 week follow-up. Results Three hundred eighty-two patents completed bot an initial and follow-up survey. 86.4% reported complete anosmia and a further 11.5% a very severe loss of smell at the time of completing the first survey. At follow-up 1 week later, there is already significant improvement in self-rating of severity of olfactory loss. 80.1% report lower severity scores at follow-up, 17.6% are unchanged and 1.9% are worse. 11.5% already report compete resolution at follow up, while 17.3% report persistent complete loss of smell, with reported duration being 1 to over 4 weeks. This is reflected in the overall cumulative improvement rate of 79% patients overall in the interval between surveys. Conclusions A review of the growing evidence base supports the likelihood that out cohort have suffered olfactory loss as part of COVID-19 infection. While early recovery rates are encouraging, long term rates will need to be further investigated and there may be an increase in patients with persistent post-viral loss as a result of the pandemic. We further call for loss of sense of smell to be formerly recognised as a marker of COVID-19 infection.