MANGANESE(II) N,N'-DIPYRIDOXYLETHYLENEDIAMINE-N,N'-DIACETATE 5,5'-BIS(PHOSPHATE) - SYNTHESIS AND CHARACTERIZATION OF A PARAMAGNETIC CHELATE FOR MAGNETIC-RESONANCE IMAGING ENHANCEMENT
MANGANESE(II) N,N'-DIPYRIDOXYLETHYLENEDIAMINE-N,N'-DIACETATE 5,5'-BIS(PHOSPHATE) - SYNTHESIS AND CHARACTERIZATION OF A PARAMAGNETIC CHELATE FOR MAGNETIC-RESONANCE IMAGING ENHANCEMENT
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DOI：
10.1021/ic00302a019
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发表时间：
1989-02-08
影响因子：
4.6
通讯作者：
RAYMOND, KN
中科院分区：
文献类型：
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作者：
ROCKLAGE, SM;CACHERIS, WP;RAYMOND, KN
描述了新配体 A,A-二吡啶氧基乙二胺-A,A'-二乙酸 5, 5'-双（磷酸盐）（DPDP，二磷酸二吡哆醛）的合成和表征。测定了 DPDP 与 Mn (II)、Zn (II)、Cu (II) 和 Fe (III) 配合物的溶液平衡性质，MnDPDP6-、ZnDPDP6-、CuDPDP6- 和 FeDPDP5- 的 log KML 值分别为 15.10、18.95、22.08 和 33.52。盐 CaNa2MnC22H26N4014P2, 21H20 (1) 的晶体是单斜晶系，空间群 C2/c（编号 15），a= 24.490 (3) A，b= 14.440 (2) A，c= 30.703 (4) A，ß= 112.747 (12)，Z= 8。不对称单元包含1个MnDPDP阴离子、1个钙阳离子、2个钠阳离子和21个水分子。锰(II)氧化态通过化学计量、Mn-O1、Mn-08、Mn-N2和Mn-N4键距以及磁化率测量来确认。讨论了 MnDPDP 在磁共振成像增强中的体内应用。
The synthesis and characterization of the new ligand A, A-dipyridoxylethylenediamine-A, A'-diacetic acid 5, 5'-bis (phosphate)(DPDP, for dipyridoxal diphosphate) are described. The solution equilibrium properties of DPDP and the Mn (II), Zn (II), Cu (II), and Fe (III) complexes have been determined, log KML values are 15.10, 18.95, 22.08, and 33.52 for MnDPDP6-, ZnDPDP6-, CuDPDP6-, and FeDPDP5-, respectively. Crystals of the salt CaNa2MnC22H26N4014P2, 21H20 (1) are monoclinic, space group C2/c (No. 15), with a= 24.490 (3) A, b= 14.440 (2) A, c= 30.703 (4) A, ß= 112.747 (12), and Z= 8. The asymmetric unit contains 1 MnDPDP anion, 1 calcium cation, 2 sodium cations, and 21 water molecules. The manganese (II) oxidation state was confirmed by the stoichiometry, by the Mn-Ol, Mn-08, Mn-N2, and Mn-N4 bond distances, and by magnetic susceptibility measurements. In vivo applications of MnDPDP for magnetic resonance imaging enhancement are discussed.