Cavum septum pellucidum and its increased prevalence in schizophrenia: A neuroembryological classification
Cavum septum pellucidum and its increased prevalence in schizophrenia: A neuroembryological classification
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DOI：
10.1176/appi.neuropsych.16.1.41
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发表时间：
2004-12-01
影响因子：
2.9
通讯作者：
Albanese, AM
中科院分区：
文献类型：
--
作者：
Galarza, M;Merlo, AB;Albanese, AM
通过脑磁共振成像研究了32名女性（平均年龄= 52.9岁[SD = 9.2]）诊断为残留精神分裂症的患者和19名女性（平均年龄= 51.1岁[SD = 12.7]）对照受试者。沿着透明隔的整个表面，在所有受试者中进行1-mm冠状切片。作者根据胚胎发育将透明隔腔分为三种类型。精神分裂症患者的空洞发生率显著高于对照组（χ 2 = 6.112。p < 0.05）。没有发现与先前描述的形态学脑变化的其他显著关联。尽管在先前的报告中发现了该结果（DeGreef等人，1992; DeLisi等人，1993），我们的讨论集中在透明隔的神经发育理论及其与精神分裂症的可能联系。
Thirty-two female (mean age = 52.9 years [SD = 9.2]) patients with a diagnosis of residual schizophrenia and 19 female (mean age = 51.1 years [SD = 12.7]) control subjects were studied through cerebral Magnetic Resonance Imaging. Along the entire surface of the septum pellucidum, 1-mm coronal slices were performed in all subjects. The authors classified the cavum septum pellucidum into three types based on embryological development. The prevalence of a cavum was significantly higher in the patients with schizophrenza (Chi square 6.112. p < 0.05). No other significant associations with previously described morphological brain changes were found. Although this result was found in previous reports (DeGreef et al., 1992; DeLisi et al., 1993), our discussion focused on the neurodevelopmental theory of the septum pellucidum and its possible association with schizophrenia.