Recent Progress in Palladium-Catalyzed Cascade Cyclizations for Natural Product Synthesis
Recent Progress in Palladium-Catalyzed Cascade Cyclizations for Natural Product Synthesis
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DOI：
10.1055/s-0036-1589165
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发表时间：
2018-02-01
影响因子：
2.6
通讯作者：
Inuki, Shinsuke
中科院分区：
文献类型：
--
作者：
Ohno, Hiroaki;Inuki, Shinsuke
级联反应（也称为多米诺反应）实现了天然产物核心结构的分步经济直接构建。在级联过程中使用原子经济的基元反应可以最大限度地减少废物的产生，并避免预官能化的基板。钯催化能促进多种原子经济的基元反应，是直接合成复杂杂环化合物的有效途径。在这篇简短的评论中，钯催化的级联反应的天然产物的核心结构的建设在过去的十年中报道的重点。1引言2用异亲核试剂终止的反应2.1用氮亲核试剂终止2.2用氧亲核试剂终止3用碳官能团终止的反应3.1用碳亲核试剂终止3.2用Heck型反应终止4结论
Cascade reactions (also represented as domino reactions) realize the step-economical direct construction of natural product core structures. The use of atom-economical elementary reactions in cascade processes can minimize waste production and avoid prefunctionalization of the substrates. Palladium catalysis, which promotes a variety of atom-economical elementary reactions, has long been used as a powerful approach to the direct formation of complex heterocycles. In this short review, palladium-catalyzed cascade reactions for the construction of core structures of natural products reported in the last decade are highlighted. 1 Introduction 2 Reactions Terminated with Heteronucleophiles 2.1 Termination with Nitrogen Nucleophiles 2.2 Termination with Oxygen Nucleophiles 3 Reactions Terminated with Carbon Functional Groups 3.1 Termination with Carbon Nucleophiles 3.2 Termination with Heck-Type Reactions 4 Conclusion