Associations of dietary sugar and glycemic index with adiposity and insulin dynamics in overweight Latino youth
Associations of dietary sugar and glycemic index with adiposity and insulin dynamics in overweight Latino youth
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DOI：
10.1093/ajcn/86.5.1331
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发表时间：
2007-11-01
影响因子：
7.1
通讯作者：
Goran, Michael I.
中科院分区：
文献类型：
--
作者：
Davis, Jaimie N.;Alexander, Katharine E.;Goran, Michael I.
背景：很少有研究研究儿童饮食中碳水化合物质量、肥胖和胰岛素动态之间的关系。目的：该研究的目的是确定饮食中碳水化合物的哪些方面，特别是膳食糖、纤维、血糖指数或血糖负荷，与超重的拉丁裔儿童的肥胖和胰岛素动态有关。设计：我们调查了120名有2型糖尿病家族史的超重的拉丁裔儿童(10-17岁)。饮食摄入量通过重复24小时饮食回忆来确定。采用全身双能X线骨密度仪评价肥胖程度。结果：调整协变量后，总糖(g/d)与体重指数(BMI；单位为kg/m(2))、BMI z评分、总脂肪质量呈正相关(分别为r=0.20、r=0.22、r=21；P<；P<；与SI和倾向指数呈负相关(r=-0.29和r=-0.24；P<；0.05)。控制协变量前后，膳食纤维、血糖指数和血糖负荷与肥胖或胰岛素动态变化无显著相关性。回归分析显示，在控制协变量后，总糖摄入量分别解释了BMI、BMI z评分和总脂肪质量的3.4%、4.6%和2.4%的变异，以及SI和倾向指数的变异的5.6%和4.8%(P<；0.05)。结论：在这个队列中，总糖摄入量，而不是血糖指数或血糖负荷，与较高的肥胖指标、较低的SI和较低的胰岛素分泌指标相关。
Background: Few studies have examined the relation between dietary carbohydrate quality, adiposity, and insulin dynamics in children. Objective: The objective of the study was to determine which aspects of dietary carbohydrate, specifically dietary sugar, fiber, glycemic index, or glycemic load, are associated with adiposity and insulin dynamics in overweight Latino children.Design: We examined 120 overweight Latino children (10-17 y old) with a family history of type 2 diabetes. Dietary intake was determined by repeated 24-h diet recalls. Adiposity was assessed by using total-body dual-energy X-ray absorptiometry. Insulin dynamics [insulin sensitivity (SI), acute insulin response, and disposition index (an index of beta-cell function)] were measured by using a frequently sampled intravenous-glucose-tolerance test.Results: After adjustment for covariates, total sugar (g/d) was positively correlated with body mass index (BMI; in k g/m(2)) BMI z scores, and total fat mass (r = 0.20, r = 0.22, and r = 21, respectively; P < 0.05) and negatively correlated with SI and disposition index (r = -0.29 and r = -0.24, respectively; P < 0.05). Dietary fiber, glycemic index, and glycemic load were not significantly correlated with adiposity or insulin dynamics before or after control for covariates. Regression analyses showed that total sugar intake explained an additional 3.4%, 4.6%, and 2.4% of the variance in BMI, BMI z scores, and total fat mass, respectively, and an additional 5.6% and 4.8% of the variance in SI and disposition index (P < 0.05), respectively, after control for covariates.Conclusion: In this cohort, total sugar intake, rather than glycemic index or glycemic load, was associated with higher adiposity measures, lower SI, and lower measures of insulin secretion.