Clearance of oncogenic human papillomavirus (HPV) infection: effect of smoking (United States)
Clearance of oncogenic human papillomavirus (HPV) infection: effect of smoking (United States)
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DOI：
10.1023/a:1020668232219
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发表时间：
2002-11-01
影响因子：
2.3
通讯作者：
Inserra, P
中科院分区：
文献类型：
--
作者：
Giuliano, AR;Sedjo, RL;Inserra, P
目的：本次调查的目的是评估吸烟与清除致癌人乳头瘤病毒 (HPV) 感染之间的关联。方法：对 346 名 18-35 岁女性进行了一项前瞻性队列研究。 HPV 检测采用混合捕获 II (HC II) 系统和聚合酶链式反应 (PCR) 进行，并使用反向线印迹法进行基因分型。每次访视时都会评估烟草暴露、生殖史和性史。根据吸烟状况评估了清除致癌 HPV 感染的概率和致癌 HPV 感染的持续时间。结果：无论使用 HC 11 还是 PCR 方法，曾经吸烟者保持 HPV 感染的时间明显更长（中位持续时间为 8.5 个月 vs 从未吸烟者 10.7 个月），并且与从不吸烟的女性相比，清除致癌感染的概率较低。吸烟时间与 HPV 清除率显着相关，并且观察到剂量反应。开始吸烟时年龄较大（>13岁）与清除致癌性HPV感染的可能性降低显着相关。结论：这是第一项证明吸烟通过增加致癌性HPV感染的持续时间和降低清除致癌性感染的可能性而促进早期宫颈癌事件的研究。
Objective: The purpose of this investigation was to assess the association between smoking and clearance of oncogenic human papillomavirus (HPV) infection.Methods: A prospective cohort study of 346 women aged 18-35 years was conducted. HPV testing was conducted with the Hybrid Capture II (HC II) system and polymerase chain reaction (PCR) with genotyping using the reverse line blot method. At each visit tobacco exposure, reproductive, and sexual histories were assessed. Probability of clearing an oncogenic HPV infection and duration of oncogenic HPV infections by smoking status was assessed.Results: Regardless of method used, HC 11 or PCR, ever smokers maintained an HPV infection significantly longer (median duration of 8.5 months vs 10.7 months, never vs ever smokers), and had a lower probability of clearing an oncogenic infection compared with women who never smoked. Smoking duration was significantly associated with HPV clearance, and a dose response was observed. Older age (>13 years) at smoking initiation was significantly associated with a reduced probability of clearing an oncogenic HPV infection.Conclusion: This is the first study to demonstrate that smoking promotes early cervical carcinogenic events by increasing duration of oncogenic HPV infections and decreasing probability of clearing oncogenic infections.