A nonhuman primate model of age-related bone loss: A longitudinal study in male and premenopausal female rhesus monkeys
A nonhuman primate model of age-related bone loss: A longitudinal study in male and premenopausal female rhesus monkeys
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DOI：
10.1016/s8756-3282(00)00452-x
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发表时间：
2001-03-01
期刊：
影响因子：
4.1
通讯作者：
Lane, MA
中科院分区：
文献类型：
--
作者：
Black, A;Tilmont, EM;Lane, MA
衰老与男性和绝经前女性的骨质逐渐流失有关，而女性绝经后骨质流失速度加快。尽管许多研究已经调查了手术引起的雌激素消耗导致的骨质流失，但对于动物模型中骨量与年龄相关的正常变化知之甚少，我们使用双能 X 射线吸收测定法 (DXA) 测量了 20 名绝经前女性（8-23 岁）和 29 名绝经前女性（8-27 岁）和 29 名绝经前女性（8-23 岁）和 29 名男性（8-27 岁）的四个骨骼部位的骨矿物质密度（BMD）、骨矿物质含量（BMC）和投影面积（PA），历时 4 年。年）恒河猴（Macaca mulatta）。雄性和雌性猴子的前臂 BMD 都随着年龄的增长而下降，雄性猴子的瘦体重与桡骨远端所有部位的 BMD 呈正相关，雄性猴子的血清骨钙素下降，尿液交联随着年龄的增长而增加，但雌性则不然。在雌性猿中，血清 25-羟基维生素 D 浓度随着猿类的增加而降低，在雄性中也观察到类似的趋势。总之，在雄性和雌性恒河猴中观察到前臂 BMD 与年龄相关的下降，老年雌性恒河猴的全身 BMC 随着时间的推移而下降，雄性也有类似的趋势。在雄性猴子中也观察到骨转换标志物随年龄的变化。这项纵向研究的结果表明，恒河猴是研究人类骨骼与年龄相关变化的潜在模型。 (Bone 28:395-302; 2001) (C) 2001 Elsevier Science Inc. 保留所有权利。
Aging is associated with gradual bone loss in men and premenopausal women, with an accelerated rate of loss after menopause in women. Although many studies have investigated bone loss due to surgically induced estrogen depletion, little is known regarding normal age-related changes in bone mass in animal models, We used dual-energy X-ray absorptiometry (DXA) to measure bone mineral density (BMD), bone mineral content (BMC), and projected area (PA) at four skeletal sites over 4 years in 20 premenopausal female (8-23 years) and 29 male (8-27 years) rhesus monkeys (Macaca mulatta). Forearm BMD declined with age in both male and female monkeys, Lean mass was positively associated with BMD at all sites in males acid with the distal radius in females, Serum osteocalcin declined and urinary cross-links increased with age in males but not females. Serum 25-hydroxyvitamin D concentrations decreased with ape in females, and a similar trend was observed in males. In conclusion, an age-related decline in forearm BMD was observed in male and female rhesus monkeys, Total body BMC declined over time in older females, with a similar trend in males. Changes in markers of bone turnover with age were also observed in male monkeys. The results of this longitudinal study suggest that the rhesus monkey is a potential model for age-related changes in the human skeleton. (Bone 28:395-302; 2001) (C) 2001 by Elsevier Science Inc. All rights reserved.