MicroRNAs: Role in Hepatitis C Virus pathogenesis.
MicroRNAs: Role in Hepatitis C Virus pathogenesis.
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DOI：
10.1016/j.gendis.2015.01.001
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发表时间：
2015-03-01
期刊：
影响因子：
6.8
通讯作者：
Ray, Ratna B
中科院分区：
文献类型：
--
作者：
Shrivastava, Shubham;Steele, Robert;Ray, Ranjit;Ray, Ratna B
丙型肝炎病毒（HCV）是一种全球性的健康负担，全世界估计有1.7亿至2亿人慢性感染。HCV感染仍然是慢性肝炎、肝硬化、肝细胞癌的独立危险因素，也是肝移植的主要原因。直接作用的抗病毒（DAA）药物的发现已经显示出有希望的结果，在清除患者中的HCV RNA方面的成功率超过90%，尽管长期后果仍有待评估。microRNA（miRNAs）是HCV感染建立中的重要参与者，并靶向HCV复制和增强细胞生长所需的关键宿主细胞因子。miRNA的表达改变通过控制免疫应答、增殖和凋亡等信号通路参与HCV感染相关的发病机制。miRNA正在成为肝脏内各种细胞类型之间的通讯手段。有可能开发循环miRNA作为疾病进展的生物标志物，也可以作为诊断工具，在HCV相关的终末期肝病的早期治疗干预的潜力。本文综述了近年来miRNA在HCV生命周期中的作用及其在HCV介导的肝病进展中的协同调节作用。
Hepatitis C virus (HCV) is a global health burden with an estimated 170–200 million peoples chronically infected worldwide. HCV infection remains as an independent risk factor for chronic hepatitis, liver cirrhosis, hepatocellular carcinoma, and a major reason for liver transplantation. Discovery of direct acting antiviral (DAA) drugs have shown promising results with more than 90% success rate in clearing the HCV RNA in patients, although long-term consequences remain to be evaluated. microRNAs (miRNAs) are important players in establishment of HCV infection and target crucial host cellular factors needed for productive HCV replication and augmented cell growth. Altered expression of miRNAs is involved in the pathogenesis associated with HCV infection by controlling signaling pathways such as immune response, proliferation and apoptosis. miRNA is emerging as a means of communication between various cell types inside the liver. There is likely possibility of developing circulating miRNAs as biomarkers of disease progression and can also serve as diagnostic tool with potential of early therapeutic intervention in HCV associated end stage liver disease. This review focuses on recent studies highlighting the contribution of miRNAs in HCV life cycle and their coordinated regulation in HCV mediated liver disease progression.