Association between parental myopia and the risk of myopia in a child
Association between parental myopia and the risk of myopia in a child
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DOI：
10.3892/etm.2015.2415
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发表时间：
2015-06-01
影响因子：
2.7
通讯作者：
Zhou, Xingtao
中科院分区：
文献类型：
--
作者：
Zhang, Xiaoyu;Qu, Xinhua;Zhou, Xingtao
父母近视和孩子患近视的风险之间的关系尚不清楚。因此，本研究对观察性研究的结果进行了荟萃分析，以调查父母近视与其子女患近视风险之间的关系。本研究系统地检索了MEDLINE、Embase和Ovid数据库进行相关研究。两位审稿人独立评估了数据，并从合适的研究中提取了优势比（ORs）和95%置信区间（ci）。进行异质性、发表偏倚和亚组分析。本荟萃分析包括来自16项研究的31,677名参与者，共8,393例近视（6项前瞻性队列研究，8项横断面研究和2项病例对照研究）。根据前瞻性队列、横断面和病例对照研究，当父母一方患有近视时，生育近视儿童的OR分别为1.53 （95% CI, 1.21-1.85）、1.96 （95% CI, 1.53-2.39）和2.13 (95% CI, 1.79-2.46)；当父母双方都患有近视时，生育近视儿童的OR分别为2.10 （95% CI, 1.42-2.77）、2.96 （95% CI, 2.21-3.71）和2.13 （95% CI, 1.79-2.46）。目前的研究发现，父母近视与孩子患近视的风险之间存在显著的正相关。父母双方都近视的孩子比父母一方近视的孩子患近视的风险更高。
The association between parental myopia and a child's risk of developing the condition is not well understood. Therefore, the present study conducted a meta-analysis of the results of observational studies in order to investigate the association between myopia in parents and their child's risk of developing the condition. The current study systematically examined the databases MEDLINE, Embase and Ovid for relevant studies. Two reviewers independently evaluated the data and extracted the odds ratios (ORs) and 95% confidence intervals (CIs) from the suitable studies. Heterogeneity, publication bias and subgroup analyses were performed. The present meta-analysis included 31,677 participants from 16 studies with 8,393 cases of myopia (six prospective cohort, eight cross-sectional and two case-control studies). The OR of giving birth to a child with myopia, according to the prospective cohort, cross-sectional and case-control studies, was 1.53 (95% CI, 1.21-1.85), 1.96 (95% CI, 1.53-2.39), and 2.13 (95% CI, 1.79-2.46), respectively, when one parent had myopia, and 2.10 (95% CI, 1.42-2.77), 2.96 (95% CI, 2.21-3.71), and 2.13 (95% CI, 1.79-2.46), respectively, when two parents had myopia. The current study identified a significant positive association between parental myopia and a child's risk of developing myopia. Children of two parents with myopia had a higher risk of developing myopia compared to those with one myopic parent.