First autopsy study of an Okinawan centenarian: Absence of many age-related diseases
First autopsy study of an Okinawan centenarian: Absence of many age-related diseases
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DOI：
10.1093/gerona/59.11.1195
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发表时间：
2004-11-01
影响因子：
5.1
通讯作者：
Perls, TT
中科院分区：
文献类型：
--
作者：
Bernstein, AM;Willcox, BJ;Perls, TT
与发病率压缩假说相一致，一些研究报告说，很大一部分百岁老人推迟或逃避与年龄有关的疾病。在那些长期患有这些疾病的人中，许多人的功能状况似乎比那些没有达到极端老年的年轻人更好。作者描述了第一次对冲绳日本百岁老人的尸检，她逃脱了许多与年龄有关的疾病，并在她漫长的生命结束时推迟了虚弱。她的晚年发病率模式与白色百岁老人形成对比。
Consistent with the compression-of-morbidity hypothesis, several studies have reported that a significant proportion of centenarians delay or escape age-related diseases. Of those who live with such diseases for a long time, many appear to do so with better functional status than do younger persons who do not achieve extreme old age. The authors describe the first autopsy in an Okinawan-Japanese centenarian who escaped many age-related illnesses and delayed frailty toward the end of her very long life. Her late-life morbidity pattern is contrasted with that of white centenarians.